Comparing the Effects of Vaginal Misoprostol, Vaginal Trinitroglycerin (TNG) and oral Evening Primrose Oil in Cervical Ripening at term pregnancy,

Comparing the Effects of Vaginal Misoprostol, Vaginal Trinitroglycerin (TNG) and oral Evening Primrose Oil in Cervical Ripening at term pregnancy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191115045453N1

Enrollment

201

Registered

2019-12-12

Start date

2019-12-06

Completion date

Unknown

Last updated

2019-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pregnancy.

Interventions

Intervention 1: Intervention group: In the intervention group A Pearl TNG Vaginal 400 mg construction of Zahravi company will be prescribed a dose of 4 to 6 hours to 3. Intervention 2: Intervention gr

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Pregnant women (primigravid) the term pregnancy (40 weeks onwards) Bishop Score less or equal to 4 candidate for induction of childbirth

Exclusion criteria

Exclusion criteria: History of past uterine surgery Use of intrauterine contraceptives (IUD) Any medicinal allergy Developing systemic and localized infection Developing known diseases such as diabetes, hypertension and... Existence of any uterine abnormalities.

Design outcomes

Primary

Measure	Time frame
Cervical ripening according to Bishop Score. Timepoint: Before and after 4 hours of intervention. Method of measurement: Bishop's rating table (between 0 and 13).;Baby Apgar Score. Timepoint: Minutes One and 5. Method of measurement: Apgar Scoring System (0 to 10).;Duration of prescribing medications to childbirth. Timepoint: Time of prescription medication and delivery time. Method of measurement: Based on minutes.;Drug side effects. Timepoint: Prescribed time of medication and 4 hours after drug Administration. Method of measurement: Nausea, vomiting, vaginal bleeding, fever and chills, blurred vision, diarrhea, feeling of bitter taste in the mouth, vaginal pain.;Vaginal bleeding rate. Timepoint: Postpartum. Method of measurement: It will be measured with a scale of zero to 3 (= 0 = no bleeding, 1 = bleeding), 2 = Low menstrual bleeding, 3 = severe bleeding with clot excretion.	—

Measure

Time frame

Cervical ripening according to Bishop Score. Timepoint: Before and after 4 hours of intervention. Method of measurement: Bishop's rating table (between 0 and 13).;Baby Apgar Score. Timepoint: Minutes One and 5. Method of measurement: Apgar Scoring System (0 to 10).;Duration of prescribing medications to childbirth. Timepoint: Time of prescription medication and delivery time. Method of measurement: Based on minutes.;Drug side effects. Timepoint: Prescribed time of medication and 4 hours after drug Administration. Method of measurement: Nausea, vomiting, vaginal bleeding, fever and chills, blurred vision, diarrhea, feeling of bitter taste in the mouth, vaginal pain.;Vaginal bleeding rate. Timepoint: Postpartum. Method of measurement: It will be measured with a scale of zero to 3 (= 0 = no bleeding, 1 = bleeding), 2 = Low menstrual bleeding, 3 = severe bleeding with clot excretion.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSanaz Alizadeh

Gorgan University of Medical Sciences

sanazalizadehmd@gmail.com+98 17 3222 4477

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026