Patients with neurological disorders requiring plasmapheresis..
Conditions
Interventions
Intervention 1: Intervention group: For every 1500 milliliters of plasma replacement, two vials of 20% albumin and 1400 milliliters of normal saline will be administered in each PLEX session. Interven
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients with inflammatory neurological syndromes who are candidates for plasma exchange. Adult patients aged 18 to 65 years Serum albumin level above 3 g/dL.
Exclusion criteria
Exclusion criteria: Pregnant and breastfeeding patients. Patients with heart failure, liver failure, and kidney failure (patients with nephrotic syndrome) Cirrhotic patients. Patients with cachexia and malnutrition with BMI < 17.5. Patients in an unstable hemodynamic condition, such as septic shock, acute respiratory failure, pulmonary embolism, or hypotension (systolic blood pressure below 90 mmHg). Thrombocytopenia with PLT < 100,000.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Colloid Osmotic Pressure. Timepoint: Before the start of plasmapheresis and after the completion of the last session of plasmapheresis. Method of measurement: Calculation via formula: Colloid Osmotic Pressure = (Globulin in g/dl * 1.4) + (Albumin in g/dl *5.5). | — |
Secondary
| Measure | Time frame |
|---|---|
| The level of edema based on visual examination. Timepoint: Before the start of plasmapheresis sessions and after the completion of each plasmapheresis session. Method of measurement: visual examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHadi Esmaily
Shahid Beheshti University of Medical Sciences
Outcome results
None listed