aphasia. Aphasia
Conditions
Interventions
Intervention group: ACTION treatment will be performed on patients with agrammatic aphasia with a focus on verb learning and its tense inflection in sentence structure. The treatment steps are as foll
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patient symptoms of non-fluent aphasia and aphasia quotient (AQ) between 51 to 75 on the test P-DAB-1 that represents the moderate aphasia Earn more than 50% on the subscales of Auditory Comprehension and Continuous Instructions on the P-DAB-1 test Agrammatic sentence production according to descriptive speech (Bird's Nest) and story retelling (three kids) in a way that speech is distorted and non-fluent; the percentage of sentences is reduced, and production of grammatical morphemes and verbs is reduced Difficulty in the verb tense inflection with less than 50 % in accuracy of regular and irregular verb tense inflection The ability to read in the subtest of single word reading in Bilingual Aphasia Test (BAT) Right-handed patient (using Edinburgh scale) Patients who are Persian monolingual or are fluent in Persian if they are bilingual Normal or near normal visual ability Normal or near normal hearing Minimum 9th grade education The patient has a stroke lesion on the left side of the brain, which last at least six months of its occurrence Aged between 18 - 65 years old
Exclusion criteria
Exclusion criteria: History of neurological and psychological problems, speech and language problems, and learning problems Patients with apraxia Patients with Dysarthria in informal assessment Sign of claustrophobia Pregnant female subjects Subjects who have metal prosthesis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Trained and generalization verb tense inflection score. Timepoint: verb tense inflection assessment for 17 times: 3 baselines, 12 during treatment (once per week for 12 weeks), 14 and 30 days after treatment. Method of measurement: verb tense inflection assessment test.;Trained and generalization sentence production score. Timepoint: sentence production assessment for 17 times: 3 baselines, 12 during treatment (once per week for 12 weeks), 14 and 30 days after treatment. Method of measurement: sentence production test.;The place of the activated brain area. Timepoint: brain activation imaging 2 times: once pre-treatment and once after treatment. Method of measurement: functional magnetic resonance imaging. | — |
Secondary
| Measure | Time frame |
|---|---|
| Sentence production score. Timepoint: sentence production assessment for 17 times: 3 baselines, 12 during treatment (once per week for 12 weeks), 14 and 30 days after treatment. Method of measurement: sentence production assessment test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactVahid Valinejad
Tehran University of Medical Sciences
Outcome results
None listed