Efficacy and saftey of fractional CO2 Laser and miconeedling in improvement of infraorbital hyperpigmentation

Efficacy and saftey of combination threapy with fractional CO2 Laser and topical tranexamic acid versus combination of microneedling and topical tranexamic acid in improvement of infraorbital hyperpigmentation

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191111045399N1

Enrollment

Registered

2019-11-13

Start date

2018-09-23

Completion date

Unknown

Last updated

2019-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infraorbital hyperpigmentation.

Interventions

Intervention group: Persons with infraorbital hyperpigmentation.

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Not using other treatments during the study Having complete satisfaction with all therapeutic sessions

Exclusion criteria

Exclusion criteria: Any active disease in the treatment area Previous history of keloid and hypertrophic scars A history of coagulopathy or anti-coagulant use Uncontrolled diabetes or hypertension Recent use of photosensitizing drugs History of inherited or acquired connective tissue diseases Known sensitivity to topical lidocaine Unrealistic expectation Perform cosmetic procedures in the treatment area in the past 12 months Pregnancy and lactation Known immunodeficiency

Design outcomes

Primary

Measure	Time frame
Percentage of improvement of infraorbital hyperpigmentation after 3 sessions of treatment. Timepoint: Photograph of the first session, beginning of the second and third sessions, one month after the last session and three months after the last session. Method of measurement: Ask the patient and review the imaging results.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactReza Ghandehari

Shahid Beheshti University of Medical Sciences

reza.ghandehari@sbmu.ac.ir+98 21 2240 3395

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026