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Effects of atorvastatin and rosuvastatin on prevention of atrial fibrillation

Comparison of effects of atorvastatin and rosuvastatin in the prevention of atrial fibrillation in patients undergoing coronary artery bypass graft

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20191109045384N1
Enrollment
200
Registered
2020-03-11
Start date
2019-02-20
Completion date
Unknown
Last updated
2020-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial fibrillation post coronary artery bypass graft. Paroxysmal atrial fibrillation

Interventions

Intervention 1: Intervention group: Administration of rosuvastatin (chemical formula (C22H27FN3O6S)2Ca) 20 mg / day (manufactured by Atiya Pharmaceutical New Technologies (FNDA)) one week before coron

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to No maximum

Inclusion criteria

Inclusion criteria: The preoperative EKG of the patient must have sinus rhythm For the study, the patient must have satisfaction The patient must be a candidate for elective surgery The CABG surgery of the patient should be on pump

Exclusion criteria

Exclusion criteria: Urgent CABG surgery Previous cardiac surgery Cardiac surgery except CABG Left ventricular ejection fraction less than or equal to 25% Diameter of left atrium more than 6 cm in echocardiography Need to inotropic agents after surgery Being dependent on pace maker after surgery The patient's rhythm shouldn't be sinus. Hyperthyroidism Aortic and mitral valves disorder more than moderate Renal failure

Design outcomes

Primary

MeasureTime frame
Incidence rate of atrial fibrillation post coronary artery bypass graft. Timepoint: Holter monitoring for 72 hours and daily ECG for one week and if it continues after one week, daily ECG will be taken until discharge.(up to 1 month). Method of measurement: Holter momitor and ECG devices.

Secondary

MeasureTime frame
Incidence of diabetes and myopathy as possible complications of rosuvastatin. Timepoint: Fasting blood glucose and creatine phosphokinase measurement and clinical examination at the end of the first week and then at the end of the first month and then six months later. Method of measurement: Clinical examination and testing of fasting blood glucose and creatine phosphokinase.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Samadifar

Tabriz University of Medical Sciences

dr.zahra2011@gmail.com+98 41 3544 8657

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026