Formulation of a topical gel containing Lawsonia inermis and Aloe vera and evaluation its effects on radiation-induced dermatitis

Formulation of a topical gel containing Lawsonia inermis and Aloe vera and evaluation its effects on radiation-induced dermatitis: A randomized double-blinded placebo-controlled trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191106045356N7

Enrollment

Registered

2021-08-01

Start date

2021-08-21

Completion date

Unknown

Last updated

2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dermatitis. Dermatitis, unspecified

Interventions

Intervention 1: Intervention group: It includes 25 patients referred to the radiotherapy center who meet the inclusion criteria, whose order and type of intervention is random based on the RND () func

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients starting radiotherapy Patients aged 18 to 65 years

Exclusion criteria

Exclusion criteria: Patients with skin diseases Allergy to henna or aloe vera use the medicine for two consecutive days Severe systemic diseases such as uncontrolled diabetes, epilepsy, immune system defects, etc. Occurrence of local infection and swelling and redness at the site of dermatitis Incidence of dermatitis and the need for medical treatment of the patient

Design outcomes

Primary

Measure	Time frame
Severity of erythema or redness. Timepoint: During and after treatment, every ten days, the skin condition undergoing radiotherapy is evaluated for the severity of redness, dryness, itching, burning and pain. Method of measurement: Scoring erythema or redness using a questionnaire.;Severity of itching. Timepoint: During and after treatment, every ten days, the skin condition undergoing radiotherapy is evaluated for the severity of redness, dryness, itching, burning and pain. Method of measurement: Scoring itching using a questionnaire.;Severity of pain. Timepoint: During and after treatment, every ten days, the skin condition undergoing radiotherapy is evaluated for the severity of redness, dryness, itching, burning and pain. Method of measurement: Scoring pain using a questionnaire.;Skin dryness score. Timepoint: During and after treatment, every ten days, the skin condition undergoing radiotherapy is evaluated for the severity of redness, dryness, itching, burning and pain. Method of measurement: Scoring skin dryness using a questionnaire.	—

Measure

Time frame

Severity of erythema or redness. Timepoint: During and after treatment, every ten days, the skin condition undergoing radiotherapy is evaluated for the severity of redness, dryness, itching, burning and pain. Method of measurement: Scoring erythema or redness using a questionnaire.;Severity of itching. Timepoint: During and after treatment, every ten days, the skin condition undergoing radiotherapy is evaluated for the severity of redness, dryness, itching, burning and pain. Method of measurement: Scoring itching using a questionnaire.;Severity of pain. Timepoint: During and after treatment, every ten days, the skin condition undergoing radiotherapy is evaluated for the severity of redness, dryness, itching, burning and pain. Method of measurement: Scoring pain using a questionnaire.;Skin dryness score. Timepoint: During and after treatment, every ten days, the skin condition undergoing radiotherapy is evaluated for the severity of redness, dryness, itching, burning and pain. Method of measurement: Scoring skin dryness using a questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohsen Zabihi

Yazd University of Medical Sciences

mzabihi100@gmail.com+98 35 3820 3419

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026