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Comparison of the effect of indapamide and hydrochlorothiazide on stone residuals in patients undergoing transurethral lithotripsy (TUL): a double-blind crossover randomized clinical trial

Comparison of the effect of indapamide and hydrochlorothiazide on stone residuals in patients undergoing transurethral lithotripsy (TUL): a double-blind crossover randomized clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20191106045356N23
Enrollment
150
Registered
2025-04-23
Start date
2024-11-21
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

kidney stones. Calculus of kidney

Interventions

Intervention 1: The intervention group 1 will receive indapamide, 2.5 mg daily. Intervention 2: The intervention group 2 will receive hydrochlorothiazide 50 mg daily. Intervention 3: The control grou

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age18 to 70 years The patient is a candidate for TUL Providing consent to enter the study

Exclusion criteria

Exclusion criteria: Pregnancy or breastfeeding History of allergy to any of the study drugs Concomitant use of other diuretics Prohibition of use of any of the study drugs

Design outcomes

Primary

MeasureTime frame
The diameter of the remaining stone particles in the ureter. Timepoint: Periodically for three months. Method of measurement: Ultrasound of patients.;Serum creatinine level. Timepoint: Periodically for three months. Method of measurement: Blood test.;Systolic and diastolic blood pressure. Timepoint: Periodically for three months. Method of measurement: Sphygmomanometer.;Severity of hydronephrosis before and after surgery. Timepoint: Periodically for three months. Method of measurement: Ultrasound.;Glomerular filtration. Timepoint: Periodically for three months. Method of measurement: Blood test.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Mohsen Zabihi

Yazd University of Medical Sciences

mzabihi100@gmail.com+35 3820 3419

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026