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The effect of fluconazole lozenge on oral candidiasis

The effect of fluconazole lozenge on oral candidiasis in immunocompromised patients: an experimental study and a randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20191106045356N16
Enrollment
50
Registered
2023-01-25
Start date
2022-12-06
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral candidiasis. Candidal stomatitis

Interventions

Intervention 1: Intervention group: Including 25 patients hospitalized in Yazd hospitals and undergoing cancer chemotherapy, who were diagnosed with oral candidiasis and met the inclusion criteria, an

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: The patient is undergoing cancer chemotherapy in Yazd hospitals. The woman should not be pregnant or lactating. Willingness to participate in the study and complete the informed consent form Age 18 to 70 years

Exclusion criteria

Exclusion criteria: The occurrence of an allergic reaction to fluconazole Aggravation of the disease and the need for drug intervention to control the disease Non-cooperation in the use of medication

Design outcomes

Primary

MeasureTime frame
Total area of oral candidiasis lesions. Timepoint: At the beginning of the treatment and after every 2 days until 10 days, the condition of oral candidiasis lesions is evaluated in terms of the total area of the lesions. Method of measurement: Determining the total area of oral candidiasis lesions through Fiji software.

Secondary

MeasureTime frame
Cotton feeling in the mouth. Timepoint: the beginning of the treatment and after every 2 days up to 10 days, the condition of oral candidiasis lesions is evaluated in terms of the feeling of cotton in the mouth (score 0 to 4). Method of measurement: Scoring the feeling of cotton in the mouth using a questionnaire.;Decreased taste. Timepoint: At the beginning of treatment and after every 2 days until 10 days, the condition of oral candidiasis lesions is evaluated in terms of taste loss (score 0 to 4). Method of measurement: Scoring of taste reduction using a questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohsen Zabihi

Yazd University of Medical Sciences

mzabihi100@gmail.com+98 35 3820 3865

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026