Irritable Bowel Syndrome(IBS). Irritable bowel syndrome with mixed bowel habits [IBS-M]
Conditions
Interventions
Intervention 1: Intervention group :patients in the first group, 25 mg of doxepin capsules daily for the first week and then 50 mg (25 mg capsules twice a day) orally for 12 weeks along with memantine
Sponsors
Islamic Azad University
Eligibility
Sex/Gender
All
Age
25 Years to 65 Years
Inclusion criteria
Inclusion criteria: 25-65-year-olds who have been experiencing symptoms for more than a year since the onset of symptoms and experiencing symptoms for at least three days a week Not taking antidepressants Not taking cardiovascular drugs No use of corticosteroids.
Exclusion criteria
Exclusion criteria: One of the side effects of memantine is diarrhea, the prevalence of which is low, mild and transient, but if the patient does not tolerate it, the person will be excluded from the study. History of psychotic disorders, bipolar disorders, obsessive compulsive disorders, history of moderate to severe major depression or drug abuse in the last 6 months. Patients with suicidal thoughts and attempts. People who are pregnant or planning to become pregnant and nursing mothers Severe underlying disease History of significant weight loss (5% of body weight in six months) Gastrointestinal bleeding Patients with cardiovascular and respiratory diseases, diabetes, hyperthyroidism Liver disorders, seizures Urinary retention, benign prostate enlargement Allergy to any of the drugs used Aggravation of the disease during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of life score in IBS-QOL questionnaire in 70 patients with irritable bowel syndrome. Timepoint: At the beginning of the study and 1, 2, and 3 months after starting to take drugs (doxepin alone or doxepin and memantine together). Method of measurement: Quality of life questionnaire for irritable bowel syndrome patients (IBS-QOL).;Pain score in questionnaire (SF-MPQ-2) in 70 patients with irritable bowel syndrome. Timepoint: At the beginning of the study and 1, 2, and 3 months after starting to take drugs (doxepin alone or doxepin and memantine together). Method of measurement: McGill Pain Questionnaire (2-SF-MPQ).;Cognitive disorders score in MMSE questionnaire in 70 patients with irritable bowel syndrome. Timepoint: At the beginning of the study and 1, 2, and 3 months after starting to take drugs (doxepin alone or doxepin and memantine together). Method of measurement: Short Mental State Test Questionnaire (MMSE). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaedeh Heydari
Islamic Azad University
Outcome results
None listed