Evaluation of the effects of sertraline and Acceptance and Commitment Therapy (ACT) enriched with Compassion Focus Therapy (CFT) on depression, stress, and anxiety

Comparison of the effectiveness of pharmacotherapy with sertraline versus Acceptance and Commitment Therapy (ACT) enriched with Compassion Focus Therapy (CFT) on depression, stress, and anxiety in addict patients undergoing Methadone Maintenance Therapy (MMT)

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191106045356N1

Enrollment

Registered

2021-04-14

Start date

2021-05-22

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

in addict patients undergoing Methadone Maintenance Therapy. Mood disorder due to known physiological condition with depressive features

Interventions

Intervention 1: Intervention group: Acceptance and Commitment Therapy + Compassionate therapy, group-based acceptance and commitment sessions will be held in 8 1-hour sessions, once a week. The traini

Eligibility

Sex/Gender

Male

Age

20 Years to 45 Years

Inclusion criteria

Inclusion criteria: duration of methadon use for at least the 6 months the age range of20_45 years

Exclusion criteria

Exclusion criteria: Existence of severe mental disorder such as psychosis Existence of instant psychosis due to psychotropic consumption. Simultaneous use of NA and similar classes. Having chronic physical illnesses that affect mood and emotions. Use of opiates and morphine Not doing homework at home Failure to complete the questionnaire in pre-test and post-test

Design outcomes

Primary

Measure	Time frame
Depression score. Timepoint: 28 days after intervention. Method of measurement: Examination of the patient and based on a standard questionnaire.	—

Secondary

Measure	Time frame
Depression, stress, and anxiety. Timepoint: Before and after treatment. Method of measurement: DASS-21.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohsen Zabihi

Yazd University of Medical Sciences

mzabihi100@gmail.com+98 35 3820 3419

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026