The effect of gabapentin and celecoxib separately and together on pain in patients after tibia fracture.

Comparing the effects of using gabapentin and celecoxib separately and together on patient pain after tibia fracture surgery.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191104045328N52

Enrollment

Registered

2026-05-10

Start date

2026-05-12

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tibia fracture bone. Fracture of shaft of tibia

Interventions

Intervention 1: Celecoxib group: : Two hours prior to surgery, participants will receive a 200-mg celecoxib capsule manufactured by Exir Pharmaceutical Company (administered as two 100-mg capsules), a

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients who are candidates for tibial fracture surgery Having informed consent to participate in the study

Exclusion criteria

Exclusion criteria: Presence of significant underlying diseases, including renal, hepatic, cardiovascular diseases, hypertension, and diabetes. History of malignancy, substance abuse, or chronic use of analgesics. Presence of known hypersensitivity to the study drugs.

Design outcomes

Primary

Measure	Time frame
Pain score. Timepoint: At 2, 4, 6, 12, and 24 hours after the surgery. Method of measurement: Visual analog scale.;Postoperative narcotic used. Timepoint: Within 24 hours after the operation. Method of measurement: Patient file.;Duration of anesthesia. Timepoint: After the intervention during surgery until the patient regains consciousness. Method of measurement: Watch.	—

Secondary

Measure	Time frame
Mean arterial pressure. Timepoint: At the beginning of the study and every 10 minutes during surgery and in the first hour of recovery. Method of measurement: NIBP monitoring device.;Heart rate. Timepoint: At the beginning of the study and every 10 minutes during surgery and in the first hour of recovery. Method of measurement: Cardiac monitoring device.;Arterial blood oxygen saturation. Timepoint: At the beginning of the study and every 10 minutes during surgery and in the first hour of recovery. Method of measurement: Pulse oximetry.	—

Measure

Time frame

Mean arterial pressure. Timepoint: At the beginning of the study and every 10 minutes during surgery and in the first hour of recovery. Method of measurement: NIBP monitoring device.;Heart rate. Timepoint: At the beginning of the study and every 10 minutes during surgery and in the first hour of recovery. Method of measurement: Cardiac monitoring device.;Arterial blood oxygen saturation. Timepoint: At the beginning of the study and every 10 minutes during surgery and in the first hour of recovery. Method of measurement: Pulse oximetry.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Hesamuddin Modir

Arak University of Medical Sciences

he_modir@arakmu.ac.ir+98 38 1495 7558

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026