Postoperative Delirium. Delirium due to known physiological condition
Conditions
Interventions
Intervention 1: Dexmedetomidine group: Patients in this group will receive dexmedetomidine (0.1 µg/kg/h) as a continuous infusion from the time of anesthesia induction until admission to the recovery
Sponsors
Arak University of Medical Sciences
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients who are candidates for knee arthroplasty under general anesthesia Having informed consent to participate in the study Surgical duration between 60 and 150 minutes
Exclusion criteria
Exclusion criteria: Presence of systemic diseases and history of specific conditions, including renal, hepatic, and cardiovascular diseases, hypertension, diabetes, hematological and vascular diseases, psychotic and mental disorders, Parkinson’s disease, motion sickness, a history of chemotherapy, and malignancies. History of substance use and drug allergies, including absence of opioid use, chronic use of analgesics, hypersensitivity to the medications under study, and seasonal allergies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of delirium. Timepoint: After surgery. Method of measurement: Confusion Assessment Method.;Duration of delirium. Timepoint: After surgery. Method of measurement: By the Watch.;Time of onset of delirium. Timepoint: The first, second, and third days after surgery. Method of measurement: Patient file.;Duration until discharge from the recovery unit. Timepoint: After surgical recovery. Method of measurement: Modified Aldrete Score. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure. Timepoint: At the beginning of surgery and every 15 minutes during the operation, throughout the recovery period, and at 2, 4, and 6 hours after surgery. Method of measurement: NIBP monitoring device.;Heart rate. Timepoint: At the beginning of surgery and every 15 minutes during the operation, throughout the recovery period, and at 2, 4, and 6 hours after surgery. Method of measurement: Cardiac monitoring device.;Arterial blood oxygen saturation. Timepoint: At the beginning of surgery and every 15 minutes during the operation, throughout the recovery period, and at 2, 4, and 6 hours after surgery. Method of measurement: Pulse oximetry. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Alireza Susanabadi
Arak University of Medical Sciences
Outcome results
None listed