Skip to content

Comparison of the effects of remifentanil, Apotel, and dexmedetomidine on pain control after abdominal surgery.

Comparison of remifentanil, Apotel (Paracetamol) and dexmedetomidine in postoperative pain control of abdominal hysterectomy candidates

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20191104045328N45
Enrollment
195
Registered
2025-10-09
Start date
2025-10-17
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain control. Other acute postprocedural pain

Interventions

Intervention 1: Intervention group 1: Patients will receive 1 g Apotel, 16 mg dexamethasone, 16 mg ondansetron, and 10 mg morphine. Intervention 2: Intervention group 2: Patients will receive 16 mg de

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients scheduled for hysterectomy presenting to Sina Ashtiani Hospital. Having a written informed consent. American Society of Anesthesiologists (ASA) Physical Status Classification I, II

Exclusion criteria

Exclusion criteria: Presence of systemic diseases including renal, hepatic, cardiovascular disorders, hypertension, diabetes, or malignancy. Having a history of substance abuse or chronic analgesic consumption. Presence of known hypersensitivity to the study drugs and seasonal allergy.

Design outcomes

Primary

MeasureTime frame
Pain score. Timepoint: In the recovery room and 2, 4, 8, 12 hours after surgery. Method of measurement: Visual analog scale.;Pain relief period. Timepoint: 24 hours after surgery. Method of measurement: History and physical examination.;Opioid consumption. Timepoint: 24 hours after surgery. Method of measurement: Patient file.

Secondary

MeasureTime frame
Mean arterial pressure. Timepoint: At the beginning of surgery and every 15 minutes until the end of surgery. Method of measurement: NIBP monitoring device.;Heart rate. Timepoint: At the beginning of surgery and every 15 minutes until the end of surgery. Method of measurement: Cardiac monitoring device.;Arterial blood oxygen saturation. Timepoint: At the beginning of surgery and every 15 minutes until the end of surgery. Method of measurement: Pulse oximetry.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Alireza Kamali

Arak University of Medical Sciences

alikamaliir@yahoo.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026