Comparison of Melatonin, Caffeine, and Dextromethorphan for Facilitating Anesthesia and Reducing Pain After Lumbar Disc Surgery

Comparison of the effects of melatonin, caffeine and dextromethorphan as premedication in propofol anesthesia induction dose and the amount of sedation and the need for analgesia after lumbar disc herniation surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191104045328N41

Enrollment

Registered

2025-08-28

Start date

2025-09-06

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain after surgery. Other acute postprocedural pain

Interventions

Intervention 1: Melatonin group: Patients in this group will receive two 3 mg melatonin tablets (Razak Pharmaceutical Company, Iran), for a total oral dose of 6 mg. The tablet is dissolved in 10 ml of

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients who are candidates for lumbar disc herniation surgery Having informed consent to participate in the study Surgery performed by a surgeon

Exclusion criteria

Exclusion criteria: Having a history of systemic kidney, liver, cardiovascular disease, high blood pressure, diabetes, or malignancy Having a history of chronic opioid or painkiller use, and no known allergies to the study drugs or seasonal allergies

Design outcomes

Primary

Measure	Time frame
Propofol dosage. Timepoint: After the intervention. Method of measurement: Operating room sheet.;Pain intensity. Timepoint: In the recovery room and at 2, 6, 12, and 24 hours after surgery. Method of measurement: Visual analog scale.;Ramsey Score. Timepoint: In recovery, 2, 4, 6, 12, 24 hours after surgery. Method of measurement: By registering the Ramsey Score.	—

Secondary

Measure	Time frame
Mean arterial pressure. Timepoint: At the beginning of surgery and every 15 minutes until the end of surgery, during recovery, and two and four hours after surgery. Method of measurement: Cardiac monitoring.;Mean arterial pressure. Timepoint: At the beginning of surgery and every 15 minutes until the end of surgery, during recovery, and two and four hours after surgery. Method of measurement: Cardiac monitoring.;Arterial oxygen saturation. Timepoint: At the beginning of surgery and every 15 minutes until the end of surgery, during recovery, and two and four hours after surgery. Method of measurement: Cardiac monitoring.	—

Measure

Time frame

Mean arterial pressure. Timepoint: At the beginning of surgery and every 15 minutes until the end of surgery, during recovery, and two and four hours after surgery. Method of measurement: Cardiac monitoring.;Mean arterial pressure. Timepoint: At the beginning of surgery and every 15 minutes until the end of surgery, during recovery, and two and four hours after surgery. Method of measurement: Cardiac monitoring.;Arterial oxygen saturation. Timepoint: At the beginning of surgery and every 15 minutes until the end of surgery, during recovery, and two and four hours after surgery. Method of measurement: Cardiac monitoring.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Alireza Susanabadi

Arak University of Medical Sciences

dr.susanabadi@arakmu.ac.ir+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026