The effect of sterolix, dydrogesterone, and medroxyprogesterone acetate on poor ovarian response

Comparison of the effects of Cetrorelix, dydrogesterone and medroxyprogesterone acetate in In Vitro Fertilization (IVF) candidate patients with poor ovarian response

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191104045328N37

Enrollment

150

Registered

2025-06-07

Start date

2025-06-10

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Poor ovarian response. Ovarian dysfunction

Interventions

Intervention 1: Intervention Group 1: The treatment protocol in this group begins on the second or third day of the menstrual cycle. Starting from the second day, each patient will receive 20 milligra

Eligibility

Sex/Gender

Female

Age

No minimum to 39 Years

Inclusion criteria

Inclusion criteria: All women who are candidates for In Vitro Fertilization with poor ovarian response Absence of abnormalities in sperm morphology, motility, and function based on sperm analysis in the partner Consent to participate in the study

Exclusion criteria

Exclusion criteria: History of severe allergies or severe side effects to medications

Design outcomes

Primary

Measure	Time frame
Number of retrieved oocytes. Timepoint: After an intervention during the In vitro fertilization process. Method of measurement: Microscope.;Number of two-pronuclei (2PN) zygotes. Timepoint: After an intervention during the In vitro fertilization process. Method of measurement: Microscope.;Number of embryos available. Timepoint: After an intervention during the In vitro fertilization process. Method of measurement: Microscope.;Fertilization rate. Timepoint: After an intervention during the In vitro fertilization process. Method of measurement: Microscope.;Egg retrieval rate. Timepoint: After an intervention during the In vitro fertilization process. Method of measurement: Microscope.;Cancellation rate. Timepoint: After an intervention during the In vitro fertilization process. Method of measurement: Microscope.;Luteinizing hormone (LH) on trigger day. Timepoint: After the intervention. Method of measurement: Enzyme-Linked Immunosorbent Assay (ELISA) device.;Estradiol on trigger day. Timepoint: After the intervention. Method of measurement: Enzyme-Linked Immunosorbent Assay (ELISA) device.;Serum progesterone level on trigger day. Timepoint: After the intervention. Method of measurement: Enzyme-Linked Immunosorbent Assay (ELISA) device.;Biochemical pregnancy. Timepoint: 2 weeks after intervention. Method of measurement: Enzyme-Linked Immunosorbent Assay (ELISA) device.;Clinical pregnancy. Timepoint: 8 weeks after intervention. Method of measurement: Ultrasound.;Ongoing pregnancy. Timepoint: 10 weeks after intervention. Method of measurement: Ultrasound.	—

Measure

Time frame

Number of retrieved oocytes. Timepoint: After an intervention during the In vitro fertilization process. Method of measurement: Microscope.;Number of two-pronuclei (2PN) zygotes. Timepoint: After an intervention during the In vitro fertilization process. Method of measurement: Microscope.;Number of embryos available. Timepoint: After an intervention during the In vitro fertilization process. Method of measurement: Microscope.;Fertilization rate. Timepoint: After an intervention during the In vitro fertilization process. Method of measurement: Microscope.;Egg retrieval rate. Timepoint: After an intervention during the In vitro fertilization process. Method of measurement: Microscope.;Cancellation rate. Timepoint: After an intervention during the In vitro fertilization process. Method of measurement: Microscope.;Luteinizing hormone (LH) on trigger day. Timepoint: After the intervention. Method of measurement: Enzyme-Linked Immunosorbent Assay (ELISA) device.;Estradiol on trigger day. Timepoint: After the intervention. Method of measurement: Enzyme-Linked Immunosorbent Assay (ELISA) device.;Serum progesterone level on trigger day. Timepoint: After the intervention. Method of measurement: Enzyme-Linked Immunosorbent Assay (ELISA) device.;Biochemical pregnancy. Timepoint: 2 weeks after intervention. Method of measurement: Enzyme-Linked Immunosorbent Assay (ELISA) device.;Clinical pregnancy. Timepoint: 8 weeks after intervention. Method of measurement: Ultrasound.;Ongoing pregnancy. Timepoint: 10 weeks after intervention. Method of measurement: Ultrasound.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Azam Muslimi

Arak University of Medical Sciences

azammoslemi@arakmu.ac.ir+98 86 3417 3601

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026