Combination of ephedrine with chlorpheniramine and haloperidol in the prevention of postoperative nausea and vomiting.

Pretreatment comparison of ephedrine combination with chlorpheniramine and haloperidol in prevention of nausea and vomiting after laparoscopic cholecystectomy

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191104045328N34

Enrollment

120

Registered

2025-04-23

Start date

2025-05-05

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nausea and vomiting after laparoscopic gallbladder surgery. Nausea and vomiting

Interventions

Intervention 1: Group (A) Ephedrine + Distilled Water: In this group, 0.5 mg/kg ephedrine (Biotika Pharmaceutical Company, Hungary) along with 1 cc of distilled water will be injected intramuscularly

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients who are candidates for laparoscopic gallbladder surgery All patients should be under general anesthesia. Age 18-65 years Surgery performed by a surgeon Surgery duration: 60 to 150 minutes Consent to participate in the study

Exclusion criteria

Exclusion criteria: Presence of kidney, liver, and cardiovascular disease A history of high blood pressure, diabetes, malignancy, and blood and vascular problems History of mental and psychotic illnesses Presence of Parkinson's disease, movement disorders, or history of chemotherapy Known sensitivity to the study drugs and absence of seasonal allergies

Design outcomes

Primary

Measure	Time frame
Nausea and vomiting score. Timepoint: In recovery, 2, 4, 6, 12, 24 hours after surgery. Method of measurement: Nausea and vomiting scale.;Severity of nausea and vomiting. Timepoint: In recovery, 2, 4, 6, 12, 24 hours after surgery. Method of measurement: Visual analog scale.;The need for anti-nausea medication. Timepoint: After surgery. Method of measurement: The dose of metoclopramide required by patients 24 hours after surgery.	—

Measure

Time frame

Nausea and vomiting score. Timepoint: In recovery, 2, 4, 6, 12, 24 hours after surgery. Method of measurement: Nausea and vomiting scale.;Severity of nausea and vomiting. Timepoint: In recovery, 2, 4, 6, 12, 24 hours after surgery. Method of measurement: Visual analog scale.;The need for anti-nausea medication. Timepoint: After surgery. Method of measurement: The dose of metoclopramide required by patients 24 hours after surgery.

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Secondary

Measure	Time frame
Ramsey Score. Timepoint: In recovery, 2, 4, 6, 12, 24 hours after surgery. Method of measurement: By registering the Ramsey Score.;Mean arterial pressure. Timepoint: At the beginning of surgery and every 15 minutes until the end of surgery, during recovery, and two and four hours after surgery. Method of measurement: Cardiac monitoring.;Heart rate. Timepoint: At the beginning of surgery and every 15 minutes until the end of surgery, during recovery, and two and four hours after surgery. Method of measurement: Cardiac monitoring.;Arterial oxygen saturation. Timepoint: At the beginning of surgery and every 15 minutes until the end of surgery, during recovery, and two and four hours after surgery. Method of measurement: Pulse oximetry.	—

Measure

Time frame

Ramsey Score. Timepoint: In recovery, 2, 4, 6, 12, 24 hours after surgery. Method of measurement: By registering the Ramsey Score.;Mean arterial pressure. Timepoint: At the beginning of surgery and every 15 minutes until the end of surgery, during recovery, and two and four hours after surgery. Method of measurement: Cardiac monitoring.;Heart rate. Timepoint: At the beginning of surgery and every 15 minutes until the end of surgery, during recovery, and two and four hours after surgery. Method of measurement: Cardiac monitoring.;Arterial oxygen saturation. Timepoint: At the beginning of surgery and every 15 minutes until the end of surgery, during recovery, and two and four hours after surgery. Method of measurement: Pulse oximetry.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Alireza Susanabadi

Arak University of Medical Sciences

dr.susanabadi@arakmu.ac.ir+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026