The effect of gabapentin, celecoxib, and melatonin on the induction dose of propofol anesthesia in knee replacement surgery under general anesthesia.

Comparison of the effect of gabapentin, celecoxib and melatonin as premedication on the induction dose of propofol in knee joint replacement surgery under general anesthesia.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191104045328N32

Enrollment

111

Registered

2025-02-18

Start date

2025-02-28

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee replacement surgery. Fracture of bone following insertion of orthopedic implant, joint prosthesis, or bone plate

Interventions

Intervention 1: Celexib group: In this group, 200 mg Celebrex capsules manufactured by Elixir Pharmaceutical Company are prescribed 60 minutes before surgery. Intervention 2: Melatonin group: In this

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients who are candidates for knee replacement surgery Age 18-65 years Candidate for surgery on one knee Having informed consent to participate in the study Surgery by a surgeon

Exclusion criteria

Exclusion criteria: Presence of kidney, liver, and cardiovascular disease History of drug use and chronic use of painkillers Having a history of malignancy Having a history of high blood pressure and diabetes Known sensitivity to the study drugs

Design outcomes

Primary

Measure	Time frame
Propofol anesthesia induction dose. Timepoint: After surgery. Method of measurement: Propofol dosage in milligrams.;Duration of anesthesia. Timepoint: After surgery. Method of measurement: It is in minutes by watch.	—

Secondary

Measure	Time frame
Anesthesia BIS Index. Timepoint: During anesthesia. Method of measurement: BIS is assessed by electrodes during surgery.;Mean Arterial Pressure. Timepoint: At the beginning of the study and every 10 minutes during surgery and in the first hour of recovery. Method of measurement: Cardiac monitoring.;Heart rate. Timepoint: At the beginning of the study and every 10 minutes during surgery and in the first hour of recovery. Method of measurement: Cardiac monitoring.;Arterial blood oxygen saturation. Timepoint: At the beginning of the study and every 10 minutes during surgery and in the first hour of recovery. Method of measurement: Cardiac monitoring.;Pain score. Timepoint: Times 1, 3, 6, 12, and 24 hours after surgery. Method of measurement: Visual Analog Scale.	—

Measure

Time frame

Anesthesia BIS Index. Timepoint: During anesthesia. Method of measurement: BIS is assessed by electrodes during surgery.;Mean Arterial Pressure. Timepoint: At the beginning of the study and every 10 minutes during surgery and in the first hour of recovery. Method of measurement: Cardiac monitoring.;Heart rate. Timepoint: At the beginning of the study and every 10 minutes during surgery and in the first hour of recovery. Method of measurement: Cardiac monitoring.;Arterial blood oxygen saturation. Timepoint: At the beginning of the study and every 10 minutes during surgery and in the first hour of recovery. Method of measurement: Cardiac monitoring.;Pain score. Timepoint: Times 1, 3, 6, 12, and 24 hours after surgery. Method of measurement: Visual Analog Scale.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Hesamuddin Modir

Arak University of Medical Sciences

modir.he@gmail.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026