The effect of choline on fetal growth and glycemic indices in women with gestational diabetes

The effect of choline supplementation on biometric parameters of fetal growth and glycemic index in women with gestational diabetes

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191104045328N16

Enrollment

Registered

2023-09-27

Start date

2023-10-22

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gestational diabetes. Gestational diabetes mellitus

Interventions

Intervention 1: Intervention group: The intervention group (choline) will receive 2 capsules of 235 mg of choline daily from the 28th week of pregnancy for 8 weeks. Intervention 2: Control group: The

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Pregnant women who referred to Taleghani hospital's obstetrics and gynecology clinic and their gestational diabetes was diagnosed by an obstetrics and gynecology specialist. Willingness to participate in the study

Exclusion criteria

Exclusion criteria: Previous history of diabetes Taking choline supplements in the past six months Presence of fetal or chromosomal abnormalities Having polycystic ovary

Design outcomes

Primary

Measure	Time frame
The largest diameter of the fetal head. Timepoint: 28th and 36th week of pregnancy. Method of measurement: Fetal Doppler ultrasound.;Fetal weight. Timepoint: 28th and 36th week of pregnancy. Method of measurement: sonography.;Fetal abdominal circumference. Timepoint: After the eighth week of pregnancy. Method of measurement: sonography.;Amount of amniotic fluid. Timepoint: After the eighth week of pregnancy. Method of measurement: sonography.;Fetal head circumference. Timepoint: After the eighth week of pregnancy. Method of measurement: sonography.;Baby's weight. Timepoint: after birth. Method of measurement: scales.;Fasting blood sugar. Timepoint: 36th week of pregnancy. Method of measurement: Laboratory.;Blood glucose 2 hours after a meal. Timepoint: 36th week of pregnancy. Method of measurement: Laboratory.;HbA1C. Timepoint: 36th week of pregnancy. Method of measurement: Laboratory.;Insulin level. Timepoint: 36th week of pregnancy. Method of measurement: Laboratory.;Homeostatic Model Assessment for Insulin Resistance. Timepoint: 36th week of pregnancy. Method of measurement: Laboratory.	—

Measure

Time frame

The largest diameter of the fetal head. Timepoint: 28th and 36th week of pregnancy. Method of measurement: Fetal Doppler ultrasound.;Fetal weight. Timepoint: 28th and 36th week of pregnancy. Method of measurement: sonography.;Fetal abdominal circumference. Timepoint: After the eighth week of pregnancy. Method of measurement: sonography.;Amount of amniotic fluid. Timepoint: After the eighth week of pregnancy. Method of measurement: sonography.;Fetal head circumference. Timepoint: After the eighth week of pregnancy. Method of measurement: sonography.;Baby's weight. Timepoint: after birth. Method of measurement: scales.;Fasting blood sugar. Timepoint: 36th week of pregnancy. Method of measurement: Laboratory.;Blood glucose 2 hours after a meal. Timepoint: 36th week of pregnancy. Method of measurement: Laboratory.;HbA1C. Timepoint: 36th week of pregnancy. Method of measurement: Laboratory.;Insulin level. Timepoint: 36th week of pregnancy. Method of measurement: Laboratory.;Homeostatic Model Assessment for Insulin Resistance. Timepoint: 36th week of pregnancy. Method of measurement: Laboratory.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Maryam Shokrpour

Arak University of Medical Sciences

Maryam.shokrpour@arakmu.ac.ir+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026