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The effect of metformin on reducing preeclampsia

The effect of metformin on the incidence of preeclampsia in pregnant women with low pregnancy-associated plasma protein A

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20191104045328N14
Enrollment
80
Registered
2022-12-26
Start date
2023-01-10
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pre-eclampsia. Pre-eclampsia

Interventions

Intervention 1: Intervention group: Patients in this group will receive metformin 500 mg oral tablets of Exir pharmaceutical company once a day until the end of pregnancy. Intervention 2: Control grou

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
15 Years to 50 Years

Inclusion criteria

Inclusion criteria: Pregnant mothers with low pregnancy-related plasma protein A referred to kousar Clinic Normal arterial Doppler ultrasound Age 18-50 years Consent to participate in the study

Exclusion criteria

Exclusion criteria: History of intrauterine growth restriction or preeclampsia, gestational hypertension or pregnancy complications in previous pregnancies History of congenital disease History of liver or kidney failure

Design outcomes

Primary

MeasureTime frame
Functional liver enzymes. Timepoint: in the 14th, 28th, 32nd weeks of pregnancy and at the time of delivery. Method of measurement: laboratory test.;Systolic and diastolic blood pressure. Timepoint: in the 14th, 28th, 32nd weeks of pregnancy and at the time of delivery. Method of measurement: Mercury sphygmomanometer.;Proteinuria. Timepoint: in the 14th, 28th, 32nd weeks of pregnancy and at the time of delivery. Method of measurement: Urinalysis test.;Preterm delivery. Timepoint: Delivery between 20 and 37 weeks. Method of measurement: Delivery.;Low birth weight. Timepoint: Birth weight less than 2500 grams. Method of measurement: scales.;Type of delivery. Timepoint: How the baby is born. Method of measurement: Cesarean-vaginal.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Maryam Maktabi

Arak University of Medical Sciences

Dr.maryam.maktabi@gmail.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026