Comparison the effect of Single Dose versus Divided Dose of ASA on endothelial function in diabetic patients (Type2): A Randomized Clinical Trial

Comparison the effect of Single Dose (80 mg, Daily) versus Divided Dose (80 mg, BID) of Acetylsalicylic Acid on endothelial function in diabetic patients (Type2): A Randomized Clinical Trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191101045301N1

Enrollment

Registered

2020-02-12

Start date

2020-02-20

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Newly diagnosed Diabetes mellitus without complication. Type 2 diabetes mellitus without complications

Interventions

Intervention 1: Intervention group: Tab ASA, 80 mg, BID, PO (Osve Company, Iran). Intervention 2: Control group: Tab ASA, 80 mg, daily, PO (Osve Company, Iran).

Eligibility

Sex/Gender

All

Age

40 Years to No maximum

Inclusion criteria

Inclusion criteria: Age more than 40 year Diabetes Melitus ASCVD Score more than 7.5

Exclusion criteria

Exclusion criteria: Any cardiovascular disease Any cerebrovascular disease Any cardiac arrhythmia Any anti platelet or anticoagulant consumption Suffering from acute or chronic infection Platelet disturbance or bleeding tendency NSAIDs consumption in recent 14 days Platelet count less than 120000 Smoking Chronic Kidney Disease (CKD) GI Bleeding Pregnancy

Design outcomes

Primary

Measure	Time frame
Flow Mediated Dilation. Timepoint: Bse line, 1 hour after treatment,6 days after treatment( one hour before last dose), 6 days after treatment( one hour after last dose). Method of measurement: Echocardiography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Teimouri-jervekani

Esfahan University of Medical Sciences

zari.t.j@gmail.com+98 31 3261 1406

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026