cholesystit. Other acute postprocedural pain
Conditions
Interventions
Intervention group:Patients are randomly divided into three groups (ketamine, dexmedetomidine and control). Group K: In this group, 0.5 mg/kg/h of ketamine (Panpharma, Germany) is injected intravenous
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: patients with ASA class I and II patients age between 18 and 50 years
Exclusion criteria
Exclusion criteria: emergency surgery sensitivity to the drugs used in the study abuse or alcohol lack of consent to participate in the study sychiatric disorder patients who, for some reason, changed their operation from laparoscopic during surgery. The surgery is open.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: 1-2-4-6 hours after the surgery. Method of measurement: After visiting the operating room and initial examinations, all patients will have an intravenous line with an 18 size angioket. Initial monitoring will include pulse oximetry, non-invasive sphygmomanometer, and electrocardiography. Initial symptoms will be recorded and treated with midazolam 0.03 drugs. mg/kg, fentanyl 2 µgr/kg, sodium thiopental 5 mg/kg and atracurium 0.5 mg/kg are placed under anesthesia induction and then intubated,They are connected to a ventilator and are anesthetized with isoflurane 1 ml during the operation and 0.1 mg/kg morphine is given to reduce pain during the operation. The patients are randomly divided into three groups (ketamine, dexmedetomidine and control). Group K: 15 minutes before surgical incision, 0.5 mg/kg/h of ketamine (Panpharma, Germany) is injected intravenously. Group D: In this group, 15 minutes before surgical incision, 0.6 µ/kg/min of dexmedetomidine (Exir, Iran) is injected into It is injected intravenously.Group C: In this group, normal saline is injected intravenously. Primary hemodynamic parameters such as heart rate and blood pressure are recorded upon arrival, immediately after receiving the study drugs, every 5 minutes to 15 minutes, and every 15 minutes until the end of the procedure. Next, the hemodynamic parameters and duration of painlessness, VAS score will be recorded at 24, 12, 6, 1 hours after the operation. 0 no pain), up to (VAS=10, the worst type of pain after surgery). If the score is higher than 3 after the surgery, painkillers will be prepared and injected (morphine 2-3 mg). | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure and heart rate changes. Timepoint: Every 15 minutes during operation. Method of measurement: With pressure gauge and monitoring device. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyedeh Fatemeh Hosseininejad
Ahvaz University of Medical Sciences
Outcome results
None listed