Acne vulgaris. Acne vulgaris
Conditions
Interventions
20 patients are considered as 40 half faces ,and 2 comparison groups are designed as 20 right and 20 left half faces in order to omit the interindividual differences and compare each participant respo
Sponsors
Islamic Azad University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Age between 18-50 years Clinical diagnosis of mild to moderate facial acne (GAGS score ranging from 1 to 30) made by a dermatologist Discontinuation of any topical or systemic treatment for acne from at least 3 months prior to participation
Exclusion criteria
Exclusion criteria: Pregnancy or lactation, Women with hirsutism, menstrual disorders and hormonal problems, Severe grade of acne, Candidate for isotretinoin treatment, Known allergy to black seed or tretinoin, Subjects who are non-cooperative or unsatisfied with the treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acne lesion counts. Timepoint: Baseline (before intervention) and 4 , 8 weeks after intervention, and one month after discontinuation of treatments (the 12th week after baseline). Method of measurement: Independent assessment of lesion counts: comedones, papules/pustules.;Reduction of Global Acne Grading System (GAGS) score. Timepoint: Baseline (before intervention) and 4 , 8 weeks after intervention, and one month after discontinuation of treatments (the 12th week after baseline). Method of measurement: Rating of acne according to Global Acne Grading System (GAGS) by two dermatologists.;Patients satisfaction. Timepoint: 4 , 8 weeks after intervention, and one month after discontinuation of treatments (the 12th week after baseline). Method of measurement: Patient subjective satisfaction score ranging from 1 to 100.;Adverse reactions of the study medications. Timepoint: 4 , 8 weeks after intervention, and one month after discontinuation of treatments (the 12th week after baseline). Method of measurement: Patients reports and clinical assessments by two dermatologists.;Photographic assessment. Timepoint: Baseline (before intervention) and 4 , 8 weeks after intervention, and one month after discontinuation of treatments (the 12th week after baseline). Method of measurement: Digital camera.;Visiopore parameters (quantity, size, and value). Timepoint: Baseline (before intervention) and 4 , 8 weeks after intervention, and one month after discontinuation of treatments (the 12th week after baseline). Method of measurement: Visiopore device.;Skin hydration. Timepoint: Baseline (before intervention) and 4 , 8 weeks after intervention, and one month after discontinuation of treatments (the 12th week after baseline). Method of measurement: Corneometer probe.;Skin erythema. Timepoint: Baseline (before intervention) and 4 , 8 weeks after intervention, and one month after discontinuation of treatments (the 12th week after baseline). Method of measurement: mexameter probe.;Skin mel | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mehdi Rajabi
Islamic Azad University
Outcome results
None listed