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Stem cell injection and lymphedema

Evaluation of Inguinal lymph node injection of bone marrow derived mononuclear cells for volume chnages in patients with idiopathic lower extremity lymphedema

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20191019045155N4
Enrollment
6
Registered
2020-03-29
Start date
2014-04-04
Completion date
Unknown
Last updated
2020-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Idiopathic lymphedema. Lymphedema, not elsewhere classified

Interventions

Intervention group: At first, 2 cc of bone marrow aspiration is used for cellular counting and microbial testing. A buffy coat of ClinicMACS PBS/EDTA was then prepared to dilute the volume of the cell

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
10 Years to 35 Years

Inclusion criteria

Inclusion criteria: Age between 10 to 35 years old Lower limb edema Age of onset less than 35 years old Duration of diagnosis more than 72 hours Grade less than III Sub-classification of less than 3b Informed consent to enter the study

Exclusion criteria

Exclusion criteria: Heart failure Renal failure Hepatic failure History of related surgery (lymph node dissection) History of pelvic malignancy or treatment for malignancy (irradiation) Autoimmune disease History of trauma or infection, Symptoms of sleep apnea, Previous bone marrow transplant, Morbid obesity > 40 kg/m2 Lipoedema Allergic disorder Cytotoxic drugs Drugs induced lymphedema, Congenital vascular malformation Myxedema Traveling to tropical countries or suspicion to filariasis

Design outcomes

Primary

MeasureTime frame
Volume of edema in lower extremities. Timepoint: The patients were visited 2 and 6 months post-operation. Method of measurement: Limb circumference and water displacement method.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Reza Mousavi

Shahid Beheshti University of Medical Sciences

pr_shohada@sbmu.ac.ir+98 21 25719

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026