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The Effect of Vaginal Isosorbide Mononitrate Administration on Cervical Ripening before Induction of Labor

The Effect of Vaginal Isosorbide Mononitrate Administration on Cervical Ripening before Induction of Labor in primigravida

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20191018045150N1
Enrollment
64
Registered
2020-04-27
Start date
2020-02-04
Completion date
Unknown
Last updated
2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cervical ripening.

Interventions

Intervention 1: Intervention group: . In the intervention group, 40 mg Isosorbide Mononitrate tablet(manufactured by Arya pharmaceutical company) was placed in the posterior vaginal fornix. After 12

Sponsors

Islamic Azad University of Mashhad
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: primigravida mother who have gestational age over 40 weeks. primigravida mother who have singleton pregnancy. primigravida mother who have fetus in a Cephalic presentation with a Bishop score < 4.

Exclusion criteria

Exclusion criteria: Full term Primigravida who have Previous scar on the uterus. Full term Primigravida who have polyhydramnios Full term Primigravida who have blood pressre> 160/ 110 Full term Primigravida who have proteinuria = 1 Primigravida who have a history of intolerance to isosorbide mononitrate Primigravida who are candidates for cesarean section

Design outcomes

Primary

MeasureTime frame
Bishop score. Timepoint: Bishop's score is measured before the intervention, 12 hours after the first visit, and every 4 hours after the second visit. Method of measurement: bishop score scale.

Secondary

MeasureTime frame
Mother's blood pressure. Timepoint: Mother's blood pressure is measured before the intervention, 12 hours after the first visit, and every 4 hours after the second visit. Method of measurement: Mercury Barometer.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSamane Raffe

Islamic azad university of mashhad

akbari-mo@mashhad.ir+98 51 3890 9438

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026