Postbiotics and salivary IgA

evaluation of the effect of daily usage of postbiotic toothpaste on salivary IgA levels in 6- to 12-year-old children: a triple-blind randomized controlled trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191016045128N2

Enrollment

Registered

2022-03-07

Start date

2022-04-21

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

salivary levels of IgA and pH.

Interventions

Intervention 1: Intervention group: Children in this group brush their teeth twice a day for 30 days, using toothpaste containing post-biotic Bifidobacterium animalis subsp. animalis with a concentrat

Eligibility

Sex/Gender

All

Age

6 Years to 12 Years

Inclusion criteria

Inclusion criteria: 6- to 12-year-old children In mixed dentition No systemic disease

Exclusion criteria

Exclusion criteria: Any presence of inflammatory diseases Usage of antibiotics or probiotics within the 2 weeks before start of the study or through it

Design outcomes

Primary

Measure	Time frame
Salivary IgA level. Timepoint: before intervention and 30 days after intervention. Method of measurement: Saliva collection and IgA measurement by ELISA kit.	—

Secondary

Measure	Time frame
Salivary pH. Timepoint: before intervention and 30 days after intervention. Method of measurement: pH indicator strips.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSamaneh Khanehmasjedi

Ahvaz University of Medical Sciences

masjedi.samaneh@yahoo.com+98 61 3338 9516

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 10, 2026