Effect of oral Atrovastatin on inflammatory factors in patients with traumatic brain injury

Comparison of the effectiveness of low dose oral Atrovastatin on inflammatory factors in patients with Traumatic Brain Injury (TBI)

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191016045127N1

Enrollment

Registered

2020-01-12

Start date

2020-01-29

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic Brain Injury. Traumatic cerebral edema

Interventions

Intervention 1: Intervention group: Patients will receive a tablet of Atorvastatin 20mg daily in 2 week period. Intervention 2: Control group: Patients will receive a tablet of placebo daily in 2 week

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Age between 18 to 50 years old Patents with traumatic brain injury

Exclusion criteria

Exclusion criteria: patient’s lack of consent Having allergy to Atrovastatin

Design outcomes

Primary

Measure	Time frame
Leukocytosis. Timepoint: Days 1, 7, 10 and 15 after treatment. Method of measurement: Blood samples will be taken from patients and the values of White Blood Cells will be recorded in the checklist.;Leukocytopenia. Timepoint: Days 1, 7, 10 and 15 after treatment. Method of measurement: Blood samples will be taken from patients and the values of White Blood Cells will be recorded in the checklist.;Duration of Mechanical Ventilation. Timepoint: During Intervention. Method of measurement: Day.;Hospitalization. Timepoint: During Intervention. Method of measurement: Day.;Inflammatory Factors. Timepoint: 15 days after treatment. Method of measurement: Blood samples are taken from patients and the amount of inflammatory factors determined in the laboratory and will be recorded in the checklist.	—

Measure

Time frame

Leukocytosis. Timepoint: Days 1, 7, 10 and 15 after treatment. Method of measurement: Blood samples will be taken from patients and the values of White Blood Cells will be recorded in the checklist.;Leukocytopenia. Timepoint: Days 1, 7, 10 and 15 after treatment. Method of measurement: Blood samples will be taken from patients and the values of White Blood Cells will be recorded in the checklist.;Duration of Mechanical Ventilation. Timepoint: During Intervention. Method of measurement: Day.;Hospitalization. Timepoint: During Intervention. Method of measurement: Day.;Inflammatory Factors. Timepoint: 15 days after treatment. Method of measurement: Blood samples are taken from patients and the amount of inflammatory factors determined in the laboratory and will be recorded in the checklist.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamid Zareh Zadeh

Ahvaz University of Medical Sciences

zarezadeh.h@ajums.ac.ir+98 61 3374 3018

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026