Condition 1: Intraoperative hemorrhage and hematoma of a genitourinary system organ or structure complicating a genitourinary system procedure. Condition 2: Acquired absence of other parts of urinary tract. Condition 3: Malignant neoplasm of bladder, unspecified. Intraoperative hemorrhage and hematoma of a genitourinary system organ or structure complicating a genitourinary system procedure Acquired absence of other parts of urinary tract Malignant neoplasm of bladder, unspecified
Conditions
Interventions
Intervention 1: Intervention group: receive 2 grams of fibrinogen in 100 cc distilled water. Intervention 2: Control group: receive 100 cc normal saline.
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients older than 18 years old Admitted for elective radical cystectomy localized bladder cancer (T1–2N0M0)
Exclusion criteria
Exclusion criteria: Anticoagulant agent Having a known blood Abnormality or coagulopathy (abnormal values of platelet count, PT, APTT, fibrinogen, antithrombin, or Ddimer) A history of thromboembolism Chronic liver disease Chronic kidney disease with a serum creatinine level of > 2 mg/dl A preoperative plasma fibrinogen level of = 400 mg/dl intake of non-steroidal anti-inflammatory drugs within 2 days prior to surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood loss during surgery. Timepoint: at the end of surgery. Method of measurement: visual evaluation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohsen Arian nik
Shahid Beheshti University of Medical Sciences
Outcome results
None listed