The evaluation of effect of purslane and marshmallow combined extract in the Improvement of symptoms of dry mouth

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191012045067N11

Enrollment

Registered

2025-01-09

Start date

2025-01-20

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry mouth (xerostomia). Disturbances of salivary secretion

Interventions

Intervention 1: Intervention group: Syrup containing marshmallow and purslane extract prepared in the laboratory of the Traditional Medicine Research Center of Shahid Beheshti University of Medical Sc

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: To diagnose dry mouth (xerostomia), patients must exhibit symptoms of dry mouth (based on answering at least 3 positive questions from a standard dry mouth questionnaire). No alcohol, cigarettes, or other tobacco products Not pregnant - breastfeeding No history of chemotherapy or radiotherapy in the past six months Not taking corticosteroids

Exclusion criteria

Exclusion criteria: Lack of cooperation from patients

Design outcomes

Primary

Measure	Time frame
Speech disorder: Checking the need to drink water to speak and assessing the ease of speaking through a questionnaire and interview. Timepoint: Measurement time points - Persian: Measurement of outcome variables is carried out at three time points: before the start of the intervention (beginning of the study). Two weeks after the start of the intervention. Four weeks after the start of the intervention (end of the study). Method of measurement: Speech disorder: Assessing the ease of speech through a standard dry mouth.;Oral mucosal moisture: Checking the presence or absence of saliva in the floor of the mouth and the surface of the mucosa through clinical examination. Timepoint: Measurement time points - Persian: Measurement of outcome variables is carried out at three time points: before the start of the intervention (beginning of the study). Two weeks after the start of the intervention. Four weeks after the start of the intervention (end of the study). Method of measurement: Oral mucosal moisture: Through clinical examination, observing the presence or absence of saliva on the floor of the mouth and the surface of the mucosa.;Salivary secretion rate: Measuring unstimulated saliva by spitting into a test tube (milliliters per minute). Timepoint: Measurement time points - Persian: Measurement of outcome variables is carried out at three time points: before the start of the intervention (beginning of the study). Two weeks after the start of the intervention. Four weeks after the start of the intervention (end of the study). Method of measurement: Salivary secretion rate: Collecting unstimulated saliva by spitting into a test tube for 5 minutes and measuring its volume (milliliters per minute).;Mucous adhesion: Checking the adhesion of mucus to the teeth and absalon through clinical examination. Timepoint: Measurement of outcome variables is carried out at three time points: before the start of the intervention (beginning of the study). Two weeks after the start of t	—

Measure

Time frame

Speech disorder: Checking the need to drink water to speak and assessing the ease of speaking through a questionnaire and interview. Timepoint: Measurement time points - Persian: Measurement of outcome variables is carried out at three time points: before the start of the intervention (beginning of the study). Two weeks after the start of the intervention. Four weeks after the start of the intervention (end of the study). Method of measurement: Speech disorder: Assessing the ease of speech through a standard dry mouth.;Oral mucosal moisture: Checking the presence or absence of saliva in the floor of the mouth and the surface of the mucosa through clinical examination. Timepoint: Measurement time points - Persian: Measurement of outcome variables is carried out at three time points: before the start of the intervention (beginning of the study). Two weeks after the start of the intervention. Four weeks after the start of the intervention (end of the study). Method of measurement: Oral mucosal moisture: Through clinical examination, observing the presence or absence of saliva on the floor of the mouth and the surface of the mucosa.;Salivary secretion rate: Measuring unstimulated saliva by spitting into a test tube (milliliters per minute). Timepoint: Measurement time points - Persian: Measurement of outcome variables is carried out at three time points: before the start of the intervention (beginning of the study). Two weeks after the start of the intervention. Four weeks after the start of the intervention (end of the study). Method of measurement: Salivary secretion rate: Collecting unstimulated saliva by spitting into a test tube for 5 minutes and measuring its volume (milliliters per minute).;Mucous adhesion: Checking the adhesion of mucus to the teeth and absalon through clinical examination. Timepoint: Measurement of outcome variables is carried out at three time points: before the start of the intervention (beginning of the study). Two weeks after the start of t

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasoomeh Shirzaiy

Zahedan University of Medical Sciences

shirzaiy@gmail.com+98 54 3344 1824

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026