H. pylori is a gram-negative microaerophilic microorganism that infects half of the population in the world.. H. pylori can cause gastric and duodenal ulcer and predispose to gastric adenocarcinoma. Infection of H. pylori is persistent yet asymptomatic in most individuals. However, whenever the microorganism is diagnosed, it should be eradicated with the administration of antibiotics and proton pump inhibitor. The determinants of successful eradication of the microorganism include drug efficac
Conditions
Interventions
Intervention group: First group (LBR) received levofloxacin 500mg one time a day, amoxicillin 1000mg two times a day and omeprazole 20mg two times a day for two weeks. The second group (TMB) received
Sponsors
Zakho University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria for recruiting subjects in this study will be H. pylori positivity, adults older than 18 years and agreeing to be recruited.
Exclusion criteria
Exclusion criteria: Patients with prior history of antibiotics use, and those who will not agree are excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gender and age did not influence the eradication rate. Timepoint: First group (LBR) will receive levofloxacin 500mg one time a day, amoxicillin 1000mg two times a day and omeprazole 20mg two times a day for two weeks. The second group (TMB) will receive bismuth subcitrate 140mg, metronidazole 125 mg, and tetracycline 125 mg plus omeprazole 20mg twice per day for 10 days. 28 days after the completion of treatment course, H. pylori eradication will be evaluated by the 14C urease breath test (UBT). Method of measurement: The status of infection are proven by performing slide urease reaction during endoscopy or by UBT. All subjects then are assessed using the 14Carbon urea breath test after treatment conclusion. | — |
Countries
Iraq
Contacts
Public ContactIbrahim Abdulqader Naqid
Zakho University/College of Medicine
Outcome results
None listed