Evaluation of the topical effect of simvastatin on improving wound healing in diabetic patients

Produce and evaluation of the topical effect of simvastatin cream 3% on improving wound healing in diabetic patients compared with placebo: In a randomized, triple -blind, placebo-controlled clinical trial phase 2

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191010045051N1

Enrollment

Registered

2020-05-30

Start date

2020-04-04

Completion date

Unknown

Last updated

2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic foot ulcer. Type 1 diabetes mellitus with circulatory complications

Interventions

Intervention 1: Intervention group: Patients in this group twice daily for 4 weeks use 3% Simvastatin cream topically on diabetic foot ulcer.The product formulation is in the form of a cream with a ab

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Diabetic patients with foot ulcer in grade 2 or 3

Exclusion criteria

Exclusion criteria: Diabetic patients with foot ulcers with a wound surface greater than 10 cm Patients in need of amputation

Design outcomes

Primary

Measure	Time frame
Wound area. Timepoint: Measurement of wound area at baseline and 14 and 28 days after topical cream application. Method of measurement: Ruler.	—

Secondary

Measure	Time frame
Duration of hospitalization. Timepoint: 14 and 28 days after topical cream application. Method of measurement: Number of hospital stay days.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMozhde Ghomashbafzade

Ahvaz University of Medical Sciences

mozhde.ghomashbaf@gmail.com+98 61 3622 5820

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026