Condition 1: Dementia. Condition 2: Alzheimer's disease. Vascular dementia Alzheimer's disease
Conditions
Interventions
Intervention 1: Intervention group: 68 patients receive 60 probiotic capsules (2 capsules daily for one month) and this continues for three months. Each probiotic capsule contains 500 mg and contains
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: patients aged 60 and older According to the 2011NIA-AA criteria for dementia in the mild to moderate stage Obtaining informed consent
Exclusion criteria
Exclusion criteria: Chronic infections Consumption any products that contain probiotics or prebiotics during the recent 6 months Taking any kind of antibiotics during the month before starting the study History of any severe gastrointestinal diseases including celiac disease, inflammatory bowel diseases and diverticulitis or gastrointestinal surgery Alcohol consumption during 1 month before Suffering from severe heart disease, severe renal or liver impairment Patients with frontotemporal dementia (FTD), dementia with Lewy bodies (DLB), Parkinson’s disease dementia (PDD) and any demented patients in severe stage, are also excluded because of their different nature and progression manner Occurrence of delirium at the beginning of the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini Mental State Examination. Timepoint: The beginning of the study - 3 months later. Method of measurement: Mini Mental State Examination (MMSE) test.;Functional assessment staging. Timepoint: The beginning of the study - 3 months later. Method of measurement: Functional assessment staging test (FAST)? Barthel Index.;Metabolic status. Timepoint: The beginning of the study - 3 months later. Method of measurement: Chek Serum TG? Total Chol? HDL?LDL? FBS? Alb? Vit D. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShima Raeesi
Tehran University of Medical Sciences
Outcome results
None listed