The effect of phenylephrine on blood pressure and nausea and vomiting in pregnant women

Comparison of the Effect of Phenylephrine Prophylactic Infusion with Placebo Group on Hypertension and Nausea and Vomiting of Pregnant Women During Cesarean Section Under Spinal Anesthesia

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191007045023N1

Enrollment

120

Registered

2019-11-08

Start date

2019-01-01

Completion date

Unknown

Last updated

2019-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy. Pre-existing hypertension complicating pregnancy, childbirth and the puerperium

Interventions

Intervention 1: Intervention group: In the intervention group, 35 µg / kg phenylephrine was injected. Spinal anesthesia was performed with 12 mg bupivacaine 0.6% in a sitting position in the L3-L4 or

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Pregnant women 18-45 years Pregnant women candidates for cesarean section by spinal anesthesia ASA Class 1 and 2 Elective cesarean section

Exclusion criteria

Exclusion criteria: history of allergy to phenylephrine BMI>30 Kg/M2 hypertension (>140/90 mmHg) contraindication for spinal anesthesia severe cardiovascular disease prematurity emergency cesarean section inadequate analgesia after spinal anesthesia

Design outcomes

Primary

Measure	Time frame
Systolic blood pressure. Timepoint: every two minutes. Method of measurement: sphygmomanometer.;Diastolic blood pressure. Timepoint: every two minutes. Method of measurement: sphygmomanometer.;Heart rate. Timepoint: every two minutes. Method of measurement: puls oxymetrie.	—

Secondary

Measure	Time frame
Arterial pressure. Timepoint: Every two minutes. Method of measurement: Sphygmomanometer.;SPO2. Timepoint: Every two minutes. Method of measurement: Pulse oximetry.;Nausea. Timepoint: One time, imminently after delivery. Method of measurement: Observing.;PH. Timepoint: One time, imminently after delivery. Method of measurement: Blood sample.;PCO2. Timepoint: One time, imminently after delivery. Method of measurement: Blood sample.;HCO3. Timepoint: One time, imminently after delivery. Method of measurement: Blood sample.;Apgar 1. Timepoint: One time, imminently after delivery. Method of measurement: Observing.;Apgar 5. Timepoint: One time, imminently after delivery. Method of measurement: Observing.	—

Measure

Time frame

Arterial pressure. Timepoint: Every two minutes. Method of measurement: Sphygmomanometer.;SPO2. Timepoint: Every two minutes. Method of measurement: Pulse oximetry.;Nausea. Timepoint: One time, imminently after delivery. Method of measurement: Observing.;PH. Timepoint: One time, imminently after delivery. Method of measurement: Blood sample.;PCO2. Timepoint: One time, imminently after delivery. Method of measurement: Blood sample.;HCO3. Timepoint: One time, imminently after delivery. Method of measurement: Blood sample.;Apgar 1. Timepoint: One time, imminently after delivery. Method of measurement: Observing.;Apgar 5. Timepoint: One time, imminently after delivery. Method of measurement: Observing.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmineh Shafei nia

Iran University of Medical Sciences

shafeinia.a@iums.ac.ir+98 21 5560 6034

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026