Eradication of Helicobacter pylori infection by sequential regimen and standard quadruple

Comparison of sequential regimen with standard quadruple therapy on eradicating of Helicobacter pylori infection

Status

Active, not recruiting

Phases

Phase 2

Study type

Observational

Source

IRCT

Registry ID

IRCT20191007045022N1

Enrollment

160

Registered

2019-10-19

Start date

2018-08-23

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helicobacter pylori. Helicobacter pylori [H.pylori] as the cause of diseases

Interventions

Intervention 1: Intervention group for the first group: first week: omeprazole (20mg / BD) + amoxicillin (1gr / BD) and second week: omeprazole (20mg / BD) + thinidazole (500 mg / BD) + levofloxacin (

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with functional dyspepsia or gastroduodenal ulcer with indication of eradication of Helicobacter pylori infection Ability and willingness to participate in study and to give informed consent Verification of Helicobacter pylori infection by endoscopic pathological specimen

Exclusion criteria

Exclusion criteria: Previous eradication of Helicobacter pylori Use of antibiotics, PPI or chemotherapy during 4 weeks prior to study Patients with a history of gastrectomy or Complicated Peptic Ulcer. Pregnant and lactating women Patients with renal failure and heart failure

Design outcomes

Primary

Measure	Time frame
Fecal antigen reduction. Timepoint: Helicobacter pylori eradication was assessed at least 2 months after the end of antibiotic treatment and at least 2 weeks after omeprazole discontinuation via fecal antigen. Method of measurement: Fecal testing.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMayam Madani

Kashan University of Medical Sciences

madani-m@mail.Kaums.ac.ir+98 31 5550 0111

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026