Lichen planopilaris. Lichen planopilaris
Conditions
Interventions
Intervention 1: Intervention group 1: 16 patients, Methotrexate oral tablet (anti-neoplastic) made by Zahravi Pharmaceutical Co. 15 mg/week for 6 month. Intervention 2: Intervention group 2: 16 patien
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients with local disease that does not respond to topical treatment after one month Patients with extensive scalp involvement as the first line treatment. Patients should have discontinued any previous systemic medication 1 month prior to admission to the study. Ages 18-65
Exclusion criteria
Exclusion criteria: Pregnancy or lactation Leukocytes less than 3000 (leukopenia of any etiology) Platelets less than 100000 Hemoglobin less than 9 Liver enzymes more than 2 time the reference limit Positive for viral hepatitis tests Consumption of Allopurinol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lichen planopilaris Activity Index. Timepoint: Measurement of Lichen planopilaris Activity Index at the beginning of the study (prior to treatment) and 2, 4, and 6 months after the treatment. Method of measurement: Using an oral questionnaire and clinical examination of patient for items in lichen planopilaris activity index.;Photography. Timepoint: Photography at the beginning of the study(prior to treatment) and 2,4 and 6 month after treatment. Method of measurement: Professional camera for dermatologist.;Dermoscopy. Timepoint: Dermoscopy at the beginning of the study(prior to treatment) and 2,4 and 6 month after treatment. Method of measurement: Handyscope fotofinder system. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParisa Hajheidari
Esfahan University of Medical Sciences
Outcome results
None listed