Effect of exercise on immune and inflammatory factors in MS patients

The effect of eight weeks of combined training on the expression of some anti-antimicrobial and micro-RNAS related to immune, TLR-4 and TLR-2 in patients with multiple sclerosis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20191006045004N1

Enrollment

Registered

2019-11-15

Start date

2019-06-21

Completion date

Unknown

Last updated

2019-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple sclerosis. Multiple sclerosis

Interventions

Intervention 1: Intervention group: Exercise training Protocol In this study, 32 training sessions, which included a total of 8 weeks of training and 4 sessions of training each week. 3 sessions will

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Confirmed diagnosis of definite relapsing and remitting MS (RRMS) An Expanded Disability Status Scale (EDSS) Score of 1 to 4 No history of any medical condition, that would preclude participation in the exercise program Ability to participate in exercise No Participants in regular exercise in the last 6 months The age range of 20 - 40 years

Exclusion criteria

Exclusion criteria: Comorbidities that prevent participation (cardiovascular disease: metabolic disease: etc.) Corticosteroid treatment Body injury that they effectively cannot participate in the exercise program Pregnancy

Design outcomes

Primary

Measure	Time frame
The expression rate of anti-antimicrobial peptides hBD-2 and LL-37. Timepoint: Before and after 8 weeks of combined training (aerobic + resistance). Method of measurement: Measurement kits for measuring the hBD-2 and LL-37 variables with methods Real Time-PCR.;Expression rate of micro-RNAS 155; 326; 23b; 146a; 21. Timepoint: Before and after 8 weeks of combined training (aerobic + resistance). Method of measurement: Measuring kits for measuring the expression of micro-RNAS 155; 326; 23b; 146a; 21 by method Real Time -PCR.;Expression rate of TLR-4; TLR-2. Timepoint: Before and after 8 weeks of combined training (aerobic + resistance). Method of measurement: Measurement kits for measuring the expression of TLR-4 and TLR-2 with Real Time-PCR method.	—

Measure

Time frame

The expression rate of anti-antimicrobial peptides hBD-2 and LL-37. Timepoint: Before and after 8 weeks of combined training (aerobic + resistance). Method of measurement: Measurement kits for measuring the hBD-2 and LL-37 variables with methods Real Time-PCR.;Expression rate of micro-RNAS 155; 326; 23b; 146a; 21. Timepoint: Before and after 8 weeks of combined training (aerobic + resistance). Method of measurement: Measuring kits for measuring the expression of micro-RNAS 155; 326; 23b; 146a; 21 by method Real Time -PCR.;Expression rate of TLR-4; TLR-2. Timepoint: Before and after 8 weeks of combined training (aerobic + resistance). Method of measurement: Measurement kits for measuring the expression of TLR-4 and TLR-2 with Real Time-PCR method.

—

Secondary

Measure	Time frame
Expanded Disability Status Scale. Timepoint: Before and after 8 weeks of combined training (aerobic + resistance). Method of measurement: EDSS Test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaman Yousefi Saqqezi

Shahrekord University

samanyousefi25@yahoo.com+98 38 3225 4315

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026