drug addiction. Mental and behavioural disorders due to use of opioids
Conditions
Interventions
Intervention 1: Intervention group: Take oxytocin nasal sprays two puffs every 6 hours in groups with targeted group activities. Intervention 2: Intervention group: Taking placebo nasal spray 2 puffs
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: These people are all men. They are between 18 and 55 years old. They have a history of drug addiction, with the drug being discontinued and replaced with methadone. The amount of methadone consumed is between 10 and 100 mg They have been on methadone maintenance therapy for longer than 6 months now on his own offer Or, as the need arises (example with travel abroad, employment or marriage)he wants to cut off methadone consumption. But despite the high tendency to Interruption of methadone has not been able to reduce methadone levels in 14 days Recently, his methadone dose has not changed. This pations were no positive morphine test for the past 3 months.
Exclusion criteria
Exclusion criteria: There is a history of seizures Recent history of brain injury drug abuse in the past 3 months Severe suicidal thoughts with severe depression Severe allergic disease Severe neurological disorders, especially if it causes increased risk of seizure Acute cardiac abnormalities present History of psychotic disorders acute vascular disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Craving of opioids abuse. Timepoint: Days 2, 3 and 4 after discontinuing methadone. Method of measurement: Self-report based on the ten-point Likert scale.;Withdrawal sign of cutting of methadone. Timepoint: Days 2, 3 and 4 after discontinuing methadone. Method of measurement: Self-report based on the ten-point Likert scale.;Morphine and methadone test result. Timepoint: At the end of each week after discontinuing methadone until the end of the month 4. Method of measurement: Take a morphine and methadone test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Participate in group therapy. Timepoint: End of each week until the end of the fourth month after discontinuing methadone. Method of measurement: Registration of people attending grouptherapy each week by therapist.;Beck Depression and Anxiety Inventory Scale. Timepoint: Once on the first day and on the fifth to tenth day after discontinuing methadone. Method of measurement: Filling and Calculating Score of Beck Depression or Anxiety Inventory.;Calculation of Serum levels of cortisol and oxytocin. Timepoint: Once at the beginning of the first day and the second time at the fourth day after discontinuing methadone. Method of measurement: take of Blood sampling and measurement of cortisol and oxytocin levels by Kit Elisa.;Comparison of the effects of oxytocin use in group versus placebo use in group in reducing or increasing the activity of different parts of the brain. Timepoint: Once at the beginning of the first day and the second time at the fourth or fifth day after discontinuing methadone. Method of measurement: Getting fmri brain. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactshahram naderi mazjin
Tehran University of Medical Sciences
Outcome results
None listed