A Comparison of the effects of amiodarone and osmolol in patients with septic shock

A comparison of the effects of Heart Rate Control with Amiodarone and esmolol on Hemodynamic and Clinical Outcomes in Patients with Septic Shock

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190929044923N1

Enrollment

Registered

2021-01-16

Start date

2019-12-22

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

septic shock. Sepsis, unspecified organism

Interventions

Intervention 1: Intervention group: The first intervention included amiodarone group therapy: After measuring the patient's hemodynamic characteristics, cardiac output, vascular resistance by uscom, p

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: septic shock receiving vasopressor despite adequate fluid therapy Heart rate above 100 beats per minute for no apparent reason (such as fever, agitation, pain, anemia, and hypovolemia that should be treated before starting medication and hemodynamic tests) Cardiac index above 2.5 liters / minute per square meter Absence of arrhythmia

Exclusion criteria

Exclusion criteria: treatment with beta-blocker or amiodarone in the last 48 hours Patient with heart valve problems Pregnancy Pulmonary fibrosis Hypo / Hyperthyroidism Known pulmonary hypertension History of amiodarone intolerance Post CPR conditions Aortic aneurysm ARDS with PaO2 / FiO2 less than 150

Design outcomes

Primary

Measure	Time frame
Stroke volume index. Timepoint: 0,6,12,24 hour after adminstration. Method of measurement: uscom.;Cardiac output index. Timepoint: 0 612 24 hours after adminstration. Method of measurement: uscom.;Heart rate. Timepoint: 0 6 12 24 hours after adminstration. Method of measurement: heart rate monitoring device.;Vascular resistance. Timepoint: 0, 6 12 24 after adminstration. Method of measurement: uscom.;Acid lactic. Timepoint: baseline and 24hours after administration. Method of measurement: laboratory analysis.;Mean arterial pressure. Timepoint: 0, 6 12 24 after adminstration. Method of measurement: monitoring device.;Vasopressor intake rate. Timepoint: 0, 6 12 24 after adminstration. Method of measurement: View Cardex.;The amount of fluid received. Timepoint: baseline and 24hours after administration. Method of measurement: View Cardex.	—

Measure

Time frame

Stroke volume index. Timepoint: 0,6,12,24 hour after adminstration. Method of measurement: uscom.;Cardiac output index. Timepoint: 0 612 24 hours after adminstration. Method of measurement: uscom.;Heart rate. Timepoint: 0 6 12 24 hours after adminstration. Method of measurement: heart rate monitoring device.;Vascular resistance. Timepoint: 0, 6 12 24 after adminstration. Method of measurement: uscom.;Acid lactic. Timepoint: baseline and 24hours after administration. Method of measurement: laboratory analysis.;Mean arterial pressure. Timepoint: 0, 6 12 24 after adminstration. Method of measurement: monitoring device.;Vasopressor intake rate. Timepoint: 0, 6 12 24 after adminstration. Method of measurement: View Cardex.;The amount of fluid received. Timepoint: baseline and 24hours after administration. Method of measurement: View Cardex.

—

Countries

Iran (Islamic Republic of)

Contacts

Public Contactmasood khataminia

Tehran University of Medical Sciences

masoodkhataminia@yahoo.com+98 21 6634 8500

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026