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Effect of olanzapine in delirium of poisoning patient

Comparison of efficacy of haloperidol and olanzapine in the treatment of delirium patient admitted in ICU

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190928044909N1
Enrollment
36
Registered
2020-07-21
Start date
2018-11-22
Completion date
Unknown
Last updated
2020-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

delirium patient admitted in ICU.

Interventions

Intervention 1: Intervention group: olanzapine pill 5 mg, made by Marham Daroo Company and is prescribed orally every 8 hours to three days. Intervention 2: Control group: Halopiridolis pill 5 mg, ma

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria included patients over 18 years of age who had acute intoxication without dementia

Exclusion criteria

Exclusion criteria: Patients who take antipsychotic drugs for any reason Patients are using alcohol or benzodiazepine Patients who were allergic to haloperidol or olanzapine, Patients who have severe agitation

Design outcomes

Primary

MeasureTime frame
Changes in the symptoms of delirium: All symptoms related to decreased attention and memory impairment are eliminated. Response to treatment is based on changes in MDAS scores.impairment are resolved. The response to treatment is based on improvement in the MDAS score. Timepoint: Treatment results are evaluated by the researcher on days 3 and 5. Method of measurement: Delirio intensity is measured on the MDAS score, which includes 10 items and 4 points.This intensity will be rated in MDAS <= 15 as "mild", in 16 <= MDAS <= 22 as "moderate" and in 23 <= MDAS <= 30, it will be rated "severe". The remission index for this disease based on this score is MDAS values less than 10.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactJavad Mesbahi

Shahid Beheshti University of Medical Sciences

j.mesbahi1969@gmail.com+98 21 5541 9005

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026