Determining the effectiveness of lidocaine solution and dexmedetomidine on gag reflex

Effect of lidocaine solution versus dexmedetomidine on gag reflex during propofol-based sedation for patients undergoing upper gastrointestinal endoscopy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190928044907N5

Enrollment

126

Registered

2023-09-28

Start date

2023-10-02

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gag Reflex. Nausea and vomiting

Interventions

Intervention 1: Intervention group1: 50 mg of propofol (Shefafarmed) slowly intravenously over 1 minute. Intervention 2: Intervention group2: At First, 0.5 micrograms/Kg along with dexmedetomidine (Ar

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age 18-60 years American Society of Anesthesiologists Classification (ASA class) 1-2

Exclusion criteria

Exclusion criteria: Cardiovascular Diseases Respiratory Diseases Mental illnesses Patients with a history of allergies Emergency patients

Design outcomes

Primary

Measure	Time frame
Gag Reflex. Timepoint: 5, 10 and 15 minutes after the endoscope is removed from the patient's mouth. Method of measurement: Criteria for measuring the severity of nausea: No nausea: No gag during contact with high risk surfaces of the mouth such as soft palate and tonsils Hakm: Gag formation during contact with high risk surfaces of the mouth such as soft palate and tonsils Medium: Gag formation during contact with low levels Risk of mouth such as hard palate and hard floor: Creating a gag before contact with an abscess, such as when opening the mouth and seeing an abscess.	—

Measure

Time frame

Gag Reflex. Timepoint: 5, 10 and 15 minutes after the endoscope is removed from the patient's mouth. Method of measurement: Criteria for measuring the severity of nausea: No nausea: No gag during contact with high risk surfaces of the mouth such as soft palate and tonsils Hakm: Gag formation during contact with high risk surfaces of the mouth such as soft palate and tonsils Medium: Gag formation during contact with low levels Risk of mouth such as hard palate and hard floor: Creating a gag before contact with an abscess, such as when opening the mouth and seeing an abscess.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Hossein Hamidi

Babol University of Medical Sciences

s.hosseinhamidi@yahoo.com+98 11 3233 8301

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026