Infections of the skin and subcutaneous tissue. Cutaneous abscess, furuncle and carbuncle
Conditions
Interventions
Intervention 1: "Intervention group 1: received 0.5 times the minimal inhibitory concentration of antimicrobial peptides nisin, melittin, pexiganan, tilapia pisidin, and omiganan (Produced at Mashhad
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Having at least one type of wound or skin infection Participant compliance with treatment method Having conditions for frequent visits to control the treatment method BMI =18 kg/m2 and =32.0 kg/m2 with a minimum weight of 50 kg Age range between 18-65 years Informed consent to participate in the research project Non-smoker (no nicotine products for at least 3 months prior to screening)
Exclusion criteria
Exclusion criteria: People with immunodeficiency and use of immunosuppressive drugs within 14 days prior to study entry Patients who used systemic antibiotics or topical antibiotics for the study wound within 72 hours prior to study entry Pregnant and breastfeeding people Having any history of severe skin allergies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximum tolerated dose. Timepoint: Per visit (day 3, 10 and 14 during intervention and day 21 (7 days after the intervention is completed). Method of measurement: Visual observation Local Skin Reactions (LSR) and Patient-Reported Outcomes (PROs). | — |
Secondary
| Measure | Time frame |
|---|---|
| Skin Infection Rating Scale (SIRS) Score. Timepoint: At the beginning of the study and at each visit (Day 1, 3 and 10 and 14 during intervention and day 21 (7 days after completing the study)). Method of measurement: Skin Infection Rating Scale (SIRS) and Microbiological examinations of wounds or infected tissue (culture, species determination, and resistance pattern determination). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactElham Khosravi
Mashhad University of Medical Sciences
Outcome results
None listed