Knee Osteoarthrits. Primary generalized (osteo)arthritis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: All patients with mild to moderate knee osteoarthritis aged 45-75 years according to Kellgren-Lawrence criteria and rheumatologist approval Absence of rheumatic diseases such as Rheumatoid Arthritis Pain and tenderness of the knee joint resistant to medicine and conservative therapy for 3 months
Exclusion criteria
Exclusion criteria: Pregnancy Medicine allergy to Oxycodone and Lidocaine 40kg/m2<BMI History of previous prolotherapy Loosening of ligaments and knee joint History of diabetes History of hematologic disease, especially with palpitations History of taking anticoagulants such as Plavix and warfarin History of joint injection in the last 3 months History of inflammatory joint disease and history of knee joint infection People who are candidates for knee surgery with grade 4 based on Kellgren-lawrence History of joint replacement and presence of joint prosthesis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Score of WOMAC questionnaire. Timepoint: 4, 8, 12, 16, 20, 24 weeks after injection. Method of measurement: Score of WOMAC questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical and functional status of the joint and persistence of the drug for 6 months after ending the treatment. Timepoint: 6 months after ending the treatment. Method of measurement: Questionnaire and clinical assessment. | — |
Countries
Iran (Islamic Republic of)
Contacts
Mashhad University of Medical Sciences