The effect of vitamin D use on ankle-brachial index in diabetic patients

The Comparison of the effect of vitamin D and standard treatment on ankle-brachial index in type 2 diabetic patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190919044819N4

Enrollment

Registered

2021-02-13

Start date

2020-12-12

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with type 2 diabetes. Diabetes mellitus due to underlying condition

Interventions

Intervention 1: Intervention group: In addition to the standard diabetes care treatment, 1,000 units of vitamin D3 is given orally once a day for 12 weeks. Monitoring is done by phone every week to r

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with type 2 diabetes who had no vascular intervention in the 2 months prior to the study Type 2 diabetic patients who are examined by an endocrinologist for vitamin D deficiency with a serum level of 25 hydroxyvitamin D less than 30 ng / ml Have peripheral arterial disease with an ankle-arm index less than 0.9 or equal to / More than 1.3 Patients with type 2 diabetes willing to cooperate and signing the written consent.

Exclusion criteria

Exclusion criteria: Suffering from any acute illness Diabetic patients with kidney or liver dysfunction Use medications including vitamins, calcium, lipid-lowering drugs, estrogen Previous diseases that cause major changes in vitamin D and calcium metabolism, such as hyperparathyroidism or hypoparathyroidism or nephrolithiasis, or other drugs that affect bone metabolism Use any drug that alters vitamin D metabolism, such as rifampin, phenytoin, or phenobarbital.

Design outcomes

Primary

Measure	Time frame
Ankle-brachial index score. Timepoint: After 12 weeks of supplementation. Method of measurement: Vascular Doppler device.;Vitamin 25 hydroxy D levels. Timepoint: After 12 weeks of supplementation. Method of measurement: Blood tests.;Total cholesterol (TC). Timepoint: After 12 weeks of supplementation. Method of measurement: Blood tests.;Serum calcium. Timepoint: After 12 weeks of supplementation. Method of measurement: Blood tests.;Triglyceride (TG). Timepoint: After 12 weeks of supplementation. Method of measurement: Blood tests.;Low-density lipoprotein (LDL). Timepoint: After 12 weeks of supplementation. Method of measurement: Blood tests.;High-density lipoprotein (HDL). Timepoint: After 12 weeks of supplementation. Method of measurement: Blood tests.	—

Measure

Time frame

Ankle-brachial index score. Timepoint: After 12 weeks of supplementation. Method of measurement: Vascular Doppler device.;Vitamin 25 hydroxy D levels. Timepoint: After 12 weeks of supplementation. Method of measurement: Blood tests.;Total cholesterol (TC). Timepoint: After 12 weeks of supplementation. Method of measurement: Blood tests.;Serum calcium. Timepoint: After 12 weeks of supplementation. Method of measurement: Blood tests.;Triglyceride (TG). Timepoint: After 12 weeks of supplementation. Method of measurement: Blood tests.;Low-density lipoprotein (LDL). Timepoint: After 12 weeks of supplementation. Method of measurement: Blood tests.;High-density lipoprotein (HDL). Timepoint: After 12 weeks of supplementation. Method of measurement: Blood tests.

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Secondary

Measure	Time frame
BMI. Timepoint: After 12 weeks of supplementation. Method of measurement: Divide weight by height squared (kg / m2).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactLeili Yekefallah

Qazvin University of Medical Sciences

Leili_fallah@yahoo.com+98 28 3333 6001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026