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Evaluation of curcumin effect on prevention of hepatotoxicity

Evaluation of curcumin effect on prevention of hepatotoxicity induced by chemotherapeutic drugs in patients under outpatient canecr treatment

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190918044815N1
Enrollment
60
Registered
2020-09-21
Start date
2020-02-20
Completion date
Unknown
Last updated
2020-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cancer. Malignant neoplasm of central portion of breast

Interventions

Intervention 1: Intervention group: At first, 30 people were randomly selected from permutation block and received a 450 mg curcumin tablet daily and at intervals before the intervention, 3 and 6 wee

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age 30 to 60 years Definitive diagnosis of cancer that chemotherapyeutic treatment is indicated . Treated with a regimen containing paclitaxel and docetaxel Ability to take oral medication

Exclusion criteria

Exclusion criteria: Gastrointestinal bleeding pregnancy and Breastfeeding using heparin, aspirin, Clopidogrel, dipiridamol ,warfarin and ticlopidine Past medical history of hepatic disease Past medical history of peptic ulcer

Design outcomes

Primary

MeasureTime frame
Aspartate Aminotransferase. Timepoint: before intervention and 3 and 6 weeks after intervention. Method of measurement: laboratory.;Alanine transaminase. Timepoint: before intervention and 3 and 6 weeks after intervention. Method of measurement: laboratory.;Alkaline phosphatase. Timepoint: before intervention and 3 and 6 weeks after intervention. Method of measurement: laboratory.;Bilirubin. Timepoint: before intervention and 3 and 6 weeks after intervention. Method of measurement: laboratory.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Hajgholami

Esfahan University of Medical Sciences

sohrab137347@gmail.com+98 31 2225 5658

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026