Effect of synbiotic supplementation in ankylosing spondylitis

Effect of synbiotic supplementation on disease activity, Th17 cells frequency, IL-23/IL-17 axis expression and serum levels of IL-17 and IL-23 in patients with ankylosing spondylitis

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190917044794N1

Enrollment

Registered

2019-09-28

Start date

2019-09-23

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ankylosing spondylitis. Ankylosing spondylitis

Interventions

Intervention 1: Intervention group: 1 synbiotic capsule fami lact per day for 3 months from Zist Takhmir factory capsuls include: 10 9 CFU bacteria namely Lactobacilus casei, Lactobacilus Ramnosis, La

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Willing to participate Age range 20-60 years AS diagnosis by rheumatologist

Exclusion criteria

Exclusion criteria: Taking nutritional and antioxidant supplements one month prior to study Pregnancy and lactation History of other autoimmune diseases History of diabetes mellitus, IBD Gastrointestinal infection and other chronic diseases The recurrence of the disease during the study Unwilling to continue the study

Design outcomes

Primary

Measure	Time frame
Disease activity. Timepoint: Before and after intervention. Method of measurement: BASDAI and BASFI criteria.;Th17 cells frequency. Timepoint: Before and after intervention. Method of measurement: Flow cytometry.;IL-23/IL-17 axis expression. Timepoint: Before and after intervention. Method of measurement: Real-time PCR and ELISA.;Serum IL-17 cytokine. Timepoint: Before and after intervention. Method of measurement: ELISA kit.;Serum IL-23 cytokine. Timepoint: Before and after intervention. Method of measurement: ELISA kit.	—

Measure

Time frame

Disease activity. Timepoint: Before and after intervention. Method of measurement: BASDAI and BASFI criteria.;Th17 cells frequency. Timepoint: Before and after intervention. Method of measurement: Flow cytometry.;IL-23/IL-17 axis expression. Timepoint: Before and after intervention. Method of measurement: Real-time PCR and ELISA.;Serum IL-17 cytokine. Timepoint: Before and after intervention. Method of measurement: ELISA kit.;Serum IL-23 cytokine. Timepoint: Before and after intervention. Method of measurement: ELISA kit.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAida Malek Mahdavi

Tabriz University of Medical Sciences

amalek@tbzmed.ac.ir+98 41 3336 9331

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026