Analgesic efficacy of transdermal patches versus oral tablets on pain control of orthodontic patients

Analgesic efficacy of diclofenac and ketoprofen transdermal patches versus ibuprofen oral tablets on pain control after initial arch wire placement in orthodontic patients -a randomized clinical trial study

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190915044771N2

Enrollment

Registered

2024-03-04

Start date

2024-03-05

Completion date

Unknown

Last updated

2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain after initial arch wire placement in orthodontic patients.

Interventions

Intervention 1: Intervention group1: Name of the drug: Ketoprofen, How to use: Skin patch (patches with the trademark Kefentech from jeil health science company), Patch concentration: 30 mg, Frequenc

Eligibility

Sex/Gender

All

Age

18 Years to 30 Years

Inclusion criteria

Inclusion criteria: Patients who want to start fixed orthodontic treatment of 2 jaws. Patients should be in the age range of 18 to 30 years. Patients should be healthy in terms of physical condition, without any systemic disease and according to the classification of the American Society of Anesthesiology should be in ASA I group. Based on Little's Irregularity Index, patients should have 3-6 mm of crowding in both upper and lower jaws and do not need tooth extraction. Patients should not take any medication at the moment. Patients should not report a history of bleeding or gastrointestinal discomfort or any allergies after taking Asprin-like drugs such as ibuprofen, and should not have any problems using ketoprofen, diclofenac, and ibuprofen.

Exclusion criteria

Exclusion criteria: Patients who have taken any painkiller within 24 hours before treatment. Patients who cannot give informed consent. Patients who are illiterate. Patients who need restoration, root canal treatment or extraction of their teeth. Patients who have spontaneous pain in their teeth or periodontal problems do not allow to start orthodontic treatment. Patients who are pregnant or breastfeeding their babies. Patients who have a history of liver or kidney diseases or take drugs that affect these 2 organs.

Design outcomes

Primary

Measure	Time frame
Pain intensity after initial arch wire placement in orthodontic patients. Timepoint: Immediately after arch wire placement and 2, 6 hours later, while sleeping, 24, 48 hours, 3 and 7 days after treatment. Method of measurement: Numerical rating scale (NRS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Yasamin Babaee Hemmati

Rasht University of Medical Sciences

yasi.10482@gmail.com+98 13 3348 6406

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026