schizophrenia. Schizophrenia
Conditions
Interventions
To the intervention group is given 400mg extended release pentoxifylline pills from Hakim Pharmaceutical Company every 8 hours for 2 months. Pentoxifylline is a class of aminophyllins..
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: Diagnosis of schizophrenia based on DSM-5 criteria Patients aged 18-55 years Completion of the consent form by the patient or his / her family Education level at least eighth grade Absence of other concurrent psychiatric disorders Absence of liver and kidney disorders Absence of medical illness leads to psychiatric symptoms No substance use except for smoking Absence of serious cognitive impairment Absence of risk factor for bleeding Patients who are prescribed antipsychotics for risperidone, olanzapine or aripiperazole. Onset of illness under 45 years
Exclusion criteria
Exclusion criteria: Hypersensitivity reaction or any unbearable side effect caused by the drug Unwillingness to continue taking the drug and continue the project
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive scores according to Stroop, Ray, Digit span, and Wisconcin card sorting test. Timepoint: Evaluation of cognitive impairments and positive and negative symptoms of schizophrenia at baseline (before intervention) and 4 and 8 weeks after starting pentoxifylline. Method of measurement: Positive and Negative Syndrome Scale, cognitive tests include Stroop, Ray, Digit span, and Wisconcin card sorting test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Score of Positive and Negative Syndrome Scale. Timepoint: Baseline (before intervention) and 4 and 8 weeks after starting pentoxifylline. Method of measurement: Positive and Negative Syndrome Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFsrhad Faridhoseini
Mashhad University of Medical Sciences
Outcome results
None listed