Skip to content

Evaluation of efficacy of intra articular injection of mannitol in patient with knee osteoarthritis

Evaluation of efficacy of intra articular injection of mannitol versus hypertonic dextrose prolotherapy on decreasing pain and improvement of functions in patients with knee osteoarthritis

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190912044756N1
Enrollment
60
Registered
2020-08-24
Start date
2020-05-20
Completion date
Unknown
Last updated
2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of knee. Osteoarthritis of knee

Interventions

Intervention 1: Intervention group: the group that receive 5cc mannitol 5%, knee intra articular injection ,in three doses as the first dose and two weeks, four weeks , weeks after first dose and c

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
38 Years to 75 Years

Inclusion criteria

Inclusion criteria: Age: 38 to70 years old Gender: male or female Knee radiography anterior standing view have been for the last three month Have symptoms of osteoartritis include pain, crepitation for at least a month without any extra articular involvment

Exclusion criteria

Exclusion criteria: Any injection of the knee joint during the last three of months sensitivity reaction to test drug The patient have done total knee arthroplasty The patient have diseases mimicking the symptoms of knee pain such as neuropathy and radiculopathy Diseases such as rheumatoid arthritis, Reiter's syndrom, gout Uncontrolled diabetes,HBA1c more than7.5, BMI more than 40 History of knee trauma,fracture Patient's mental disorder

Design outcomes

Primary

MeasureTime frame
Knee pain. Timepoint: Two weeks ,foure weeks, eight weeks. Method of measurement: Visual Analogue Scale.

Secondary

MeasureTime frame
Function of patient. Timepoint: two weeks, four weeks, eight weeks. Method of measurement: Oxford knee score.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNasrin Barzegar

Shiraz University of Medical Sciences

Dr.nasrin.barzegar1975@gmail.com+98 71 3648 6787

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026