Adaptive Support Ventilation and Synchronized Intermittent Mandatory Ventilation in patients with ARDS

Comparison of Adaptive Support Ventilation and Synchronized Intermittent Mandatory Ventilation in patients with ARDS: A randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190908044730N1

Enrollment

Registered

2019-12-11

Start date

2017-06-01

Completion date

Unknown

Last updated

2019-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients diagnosed with acute respiratory distress syndrome (ARDS). Acute respiratory distress syndrome

Interventions

Intervention 1: Intervention group: Adaptive Support Ventilation. Intervention 2: Intervention group: Synchronized Intermittent Mandatory Ventilation.

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: expected duration of ventilation more than 72 hours no acute renal failure stable hemodynamic without using drugs BMI < 30 acute hypoxemia (P/F ratio <300 mm Hg) bilateral infiltration based on chest radiograph.

Exclusion criteria

Exclusion criteria: chronic lung disease pregnancy smoking heart failure (EF < 45%) existence of any brainstem lesions clinical evidence of left atrial hypertension apnea

Design outcomes

Primary

Measure	Time frame
Rapid shallow breathing index (RSBI). Timepoint: at baseline and daily for 3 days after intervention. Method of measurement: medical ventilator.;Spontaneous breathing rate (SBR). Timepoint: at baseline and daily for 3 days after intervention. Method of measurement: medical ventilator.;Minute volume. Timepoint: at baseline and daily for 3 days after intervention. Method of measurement: medical ventilator.;Peak inspiratory pressure (PIP). Timepoint: at baseline and daily for 3 days after intervention. Method of measurement: medical ventilator.	—

Measure

Time frame

Rapid shallow breathing index (RSBI). Timepoint: at baseline and daily for 3 days after intervention. Method of measurement: medical ventilator.;Spontaneous breathing rate (SBR). Timepoint: at baseline and daily for 3 days after intervention. Method of measurement: medical ventilator.;Minute volume. Timepoint: at baseline and daily for 3 days after intervention. Method of measurement: medical ventilator.;Peak inspiratory pressure (PIP). Timepoint: at baseline and daily for 3 days after intervention. Method of measurement: medical ventilator.

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Secondary

Measure	Time frame
ABG parameters including; PaO2, FiO2, PaCO2, HCO3 and PaO2/FiO2 ratio. Timepoint: at baseline and daily for 3 days after intervention. Method of measurement: medical ventilator.;Mean arterial blood pressure (MABP). Timepoint: at baseline and daily for 3 days after intervention. Method of measurement: medical ventilator.;Heart rate (HR). Timepoint: at baseline and daily for 3 days after intervention. Method of measurement: medical ventilator.;PH level. Timepoint: at baseline and daily for 3 days after intervention. Method of measurement: Arterial blood gas test.	—

Measure

Time frame

ABG parameters including; PaO2, FiO2, PaCO2, HCO3 and PaO2/FiO2 ratio. Timepoint: at baseline and daily for 3 days after intervention. Method of measurement: medical ventilator.;Mean arterial blood pressure (MABP). Timepoint: at baseline and daily for 3 days after intervention. Method of measurement: medical ventilator.;Heart rate (HR). Timepoint: at baseline and daily for 3 days after intervention. Method of measurement: medical ventilator.;PH level. Timepoint: at baseline and daily for 3 days after intervention. Method of measurement: Arterial blood gas test.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamideh Yari

Esfahan University of Medical Sciences

yarivida@yahoo.com+98 31 1668 5555

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026