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effects of curcumin on beta-thalassemia intermedia

Evaluation of the effects of curcumin on GDF15 gene expression and iron status in patients with beta-thalassemia intermedia

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190902044668N1
Enrollment
30
Registered
2020-08-10
Start date
2020-04-19
Completion date
Unknown
Last updated
2020-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intermediate beta-thalassemia. Beta thalassemia

Interventions

Intervention 1: Intervention group: Curcumin
Each dose contains 450 mg of turmeric rhizome powder and 50 mg of turmeric extract, which is standardized based on 5.47 mg of curcumin. three months
Three doses per day orally
Dineh Pharmaceutical Company, Iran. Intervention 2: Control group: Placebo
Each dose contains 500 mg of starch or flour. three months
Three doses per orally
Dineh Iran Pharmaceutical Company.

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: gender male Lack of sensitivity to turmeric compounds The beta-thalassemia intermedia is approved by the doctor.

Exclusion criteria

Exclusion criteria: Cardiovascular disease Diabetes Gallbladder removal

Design outcomes

Primary

MeasureTime frame
Serum iron. Timepoint: At the beginning of the study (before the intervention) and three months after the start of curcumin intake. Method of measurement: Atomic absorption spectrometry? ELISA kit.

Secondary

MeasureTime frame
Serum ferritin concentrations. Timepoint: At the beginning of the study (before the intervention) and three months after the start of curcumin intake. Method of measurement: ELISA.;C-reactive protein (CRP). Timepoint: At the beginning of the study (before the intervention) and three months after the start of curcumin intake. Method of measurement: ELISA.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactGholamhossein Tamaddon

Shiraz University of Medical Sciences

tamaddon.g@gmail.com+98 71 3227 0240

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 24, 2026