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Effect of fractional CO2 laser in combination with 5-fluorouracil cream compared to PDL laser in the treatment of hypertrophic and keloidal scars

Evaluation of the efficacy of fractional CO2 laser in combination with 5-fluorouracil cream compared to PDL laser in the treatment of hypertrophic and keloidal scars: A randomized controlled clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190901044666N4
Enrollment
24
Registered
2023-01-18
Start date
2023-01-17
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertrophic scar. Hypertrophic scar

Interventions

Intervention 1: Intervention group: Fractional CO2 laser treatment in combination with 5FU cream: Before the intervention, gentle cleaning of the desired lesion will be done using gauze soaked in norm

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients over 18 years old Patients with a confirmed diagnosis of erythematous hypertrophic scar in the number of at least 2 The size of the waste should be at least 5x5 cm square or have a length of at least 5 cm The patient is not pregnant or breastfeeding During the last two months, the patient has not received any treatment for the lesions, including laser treatment, topical or injectable corticosteroids The patient has no underlying diseases that lead to scar healing process; such as diabetes or weakened immune system The patient's cooperation in carrying out therapeutic interventions and referring for all therapeutic sessions

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Effectiveness of treatment on scar. Timepoint: Scar score measurement at the beginning of the study (before the start of the intervention) and after the end of the third session of the intervention (3 months later). Method of measurement: Vancouver scar scale (VSS) scoring method will be used to check the effectiveness of the treatment. This scale includes examination of 4 characteristics of the lesion, including: vascularity, pigmentation, height and flexibility, which are scored for each characteristic and the sum of all points will be checked in order to evaluate the improvement of the lesion.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAfsaneh Sadeghzadeh bazargan

Iran University of Medical Sciences

sadeghzadeh.a@iums.ac.ir+98 21 6435 2421

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026